AI Article Synopsis
- A common variation in the alpha1-antichymotrypsin (ACT) gene may influence Alzheimer's disease risk, particularly when paired with the ApoE epsilon4 genotype.
- Analysis of AD patients showed no instances of the ACT/AA and ApoE epsilon4/epsilon4 genotype combination in sporadic cases, indicating a lack of correlation.
- The study concludes that while ApoE epsilon4 is a known risk factor for Alzheimer's, ACT genotypes do not appear to add any additional risk for the disease.
Article Abstract
A recent observation has shown that a common polymorphism in the alpha1-antichymotrypsin (ACT) gene modifies the apolipoprotein E (ApoE) epsilon4-associated Alzheimer's disease (AD) risk identifying the combination of the ACT/AA and ApoE epsilon4/epsilon4 genotypes as a potential susceptibility marker for AD. We analyzed the segregation of the ApoE and ACT polymorphism in sporadic and familial AD patients. In none of the sporadic AD patients did we find the combination of the ACT/AA and ApoE epsilon4/epsilon4 genotypes. The frequency of ApoE epsilon4/epsilon4 homozygosity in the AD sample resulted highest for the ACT/ TT genotype (17.6%). Our data fail to confirm any additional association with AD beyond the ApoE epsilon4 allele with any ACT genotype, suggesting that ACT does not represent an additional risk factor for AD.
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| http://dx.doi.org/10.1002/ana.410400420 | DOI Listing |
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