Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359029 | PMC |
| http://dx.doi.org/10.1136/bmj.313.7061.874 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A promising future for breast cancer therapy with hydroxamic acid-based histone deacetylase inhibitors.
Bioorg Chem
January 2025
Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India. Electronic address:
Histone deacetylases (HDACs) play a critical role in chromatin remodelling and modulating the activity of various histone proteins. Aberrant HDAC functions has been related to the progression of breast cancer (BC), making HDAC inhibitors (HDACi) promising small-molecule therapeutics for its treatment. Hydroxamic acid (HA) is a significant pharmacophore due to its strong metal-chelating ability, HDAC inhibition properties, MMP inhibition abilities, and more.
View Article and Find Full Text PDFThree-dimensional kinematics in patients with anterior shoulder instability - A systematic review with meta-analysis.
J Biomech
January 2025
Instituto Brasil de Tecnologias da Saúde, Rua Visconde de Piraja, 407 suite 905, Rio de Janeiro, RJ 22410-003, Brazil; Depto. de Diagnóstico por Imagem - Escola Paulista de Medicina, Universidade Federal de São Paulo, R. Napoleão de Barros, 800, São Paulo, SP, Brazil. Electronic address:
Anterior Shoulder Instability (ASI) is a common orthopedic condition often resulting in altered shoulder kinematics. Understanding the biomechanics of the unstable shoulder is critical to determine the most appropriate treatment. This study aims to conduct the first systematic review and meta-analysis of three-dimensional (3D) shoulder kinematic studies in ASI patients.
View Article and Find Full Text PDFEffect of glyphosate on renal function: A study integrating epidemiological and experimental evidence.
Ecotoxicol Environ Saf
January 2025
Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha 410013, China. Electronic address:
Glyphosate, a widely used herbicide globally, has prompted concerns regarding its potential health impacts. This study aimed to explore the link between glyphosate exposure and renal function by combining NHANES, a zebrafish model, and metabolomics. A cross-sectional analysis of 2013-2014 NHANES data investigated the relationship between glyphosate exposure and renal function [albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR)].
View Article and Find Full Text PDFIntegrated enzyme activities and untargeted metabolome to reveal the mechanism that allow long-term biochar-based fertilizer substitution improves soil quality and maize yield.
Environ Res
January 2025
Eco-environmental Protection Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; Key Laboratory of Low-carbon Green Agriculture in Southeastern China, Ministry of Agriculture and Rural Affairs, Shanghai 201403, China. Electronic address:
Biochar-based fertilizer has potential benefits in improving soil quality and crop yield, but the biological mechanisms of soil microbial enzymes interacting with related metabolisms still need to be further investigated. In this study, we combined enzymology and untargeted metabolomics to investigate how biochar-based fertilizer substitution affects soil quality and crop yield by regulating soil enzymes and metabolites in dry-crop farmland. Our findings showed that biochar-based fertilizer substitution enhanced the activities of enzymes related to carbon, nitrogen, and phosphorus cycling, as well as influenced metabolite composition.
View Article and Find Full Text PDFThe PDR-type ABC transporter OsPDR1 is involved in leaf senescence by influencing melatonin biosynthesis in rice.
Biochem Biophys Res Commun
January 2025
National Key Laboratory of Crop Genetics and Germplasm Enhancement and Utilization, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:
Leaf senescence is a complex developmental process that is regulated by multiple genetic and environmental factors. Understanding the mechanisms underlying the regulation of leaf senescence will provide valuable insights for manipulation of this trait in crops. Here, we report that the ATP-binding cassette (ABC) transporter OsPDR1 is involved in promoting leaf senescence in rice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!