AI Article Synopsis
- A rare case of frontotemporal dementia was reported in a 28-year-old, highlighting the early onset of the condition.
- The autopsy revealed significant brain changes, including severe nerve cell loss and spongy brain tissue, which are typical signs of frontotemporal dementia.
- The study also found decreased levels of specific brain chemicals related to dopamine, raising questions about whether these biochemical changes are common in early-onset cases of the disease.
Article Abstract
1. An autopsy case of frontotemporal dementia with onset at the early age of 28 years is reported. 2. The neuropathological features consisted of limited, knife-like frontotemporal atrophy with severe neuronal loss, spongiform change and gliosis, which is compatible with the frontotemporal dementia. 3. Biochemical determinations disclosed that biogenic amines and their metabolites, predominant in the dopaminergic markers, were depleted in the damaged regions. 4. Since biochemical data in frontotemporal dementia are few in previous studies, it will be determined whether these biochemical changes are characteristic for the juvenile type of frontotemporal dementia or not.
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| http://dx.doi.org/10.1016/0278-5846(95)00264-2 | DOI Listing |
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