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Repeated hyperbaric oxygen exposure accelerates fatigue and impairs SR-calcium release in mice.
J Appl Physiol (1985)
December 2024
Center for Hyperbaric Medicine and Environmental Physiology, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Breathing hyperoxic gas is common in diving and accelerates fatigue after prolonged and repeated exposure. The mechanism(s) remain unknown but may be related to increased oxidants that interfere with skeletal muscle calcium trafficking or impair aerobic ATP production. To determine these possibilities, C57BL/6J mice were exposed to hyperbaric oxygen (HBO) for 4-h on three consecutive days or remained in room air.
View Article and Find Full Text PDFThe application of different biotechnologies in detecting the changes in MAM and their classic discoveries.
Anal Biochem
December 2024
Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China; School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:
Mitochondria-associated membrane (MAM) has been studied as a novel target for explaining the mechanisms underlying the changes in cellular function and the process of multiple diseases. This structure is a complex of proteins, it tethers mitochondria to the endoplasmic/sarcoplasmic reticulum (ER/SR) and mediates the crosstalk of ions, lipids and metabolites between the two organelles. Different component proteins play distinctive ways in influencing the structure of MAM or the cellular signal transduction.
View Article and Find Full Text PDFFast-slow analysis and bifurcations in the generation of the early afterdepolarization phenomenon in a realistic mathematical human ventricular myocyte model.
Chaos
December 2024
Departamento de Matemática Aplicada and IUMA, Computational Dynamics Group, Universidad de Zaragoza, Zaragoza E-50009, Spain.
Article Synopsis
- * This study utilizes new analytical techniques to explore how the level of calcium ions in the network sarcoplasmic reticulum affects EAD occurrence in conditions of decreased K+ current.
- * Researchers discovered nine different states of EADs that can be influenced by small changes in calcium ion concentration, providing valuable insights for potential treatment strategies.
Male Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3-4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters.
Int J Mol Sci
November 2024
Graduate Program in Translational Biomedicine (BIOTRANS), Grande Rio University (UNIGRANRIO), Duque de Caxias 25071-202, Brazil.
The central aim of this study was to investigate whether male Wistar rats chronically fed a high-fat diet (HFD) over 106 days present high levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and Na and Ca transport alterations in the left ventricle, together with dyslipidemia and decreased glucose tolerance, and to investigate the influence of Ang-(3-4). The rats became moderately overweight with an expansion of visceral adiposity. Na-transporting ATPases, sarco-endoplasmic reticulum Ca-ATPase (SERCA2a), and the abundance of Angiotensin II receptors were studied together with lipid and glycemic profiles from plasma and left-ventricle echocardiographic parameters fractional shortening (FS) and ejection fraction (EF).
View Article and Find Full Text PDFProteomic and metabolomic profiling of aged pork loin chops reveals molecular phenotypes linked to pork tenderness.
J Anim Sci
January 2024
Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Article Synopsis
- Understanding pork tenderness and quality is complicated due to insufficient knowledge of the molecular factors involved, which this study aims to address through metabolomic and proteomic profiling.
- The research involved analyzing 100 pork chops, aged for about two weeks, categorized by their tenderness using a star probe instrument, to identify differences in protein and metabolite levels.
- Significant variations in the presence of 84 proteins and 22 metabolites were found between the most tender (Category A) and least tender pork chops (Category D), suggesting that tenderness is linked to slower pH decline and changes in muscle proteins.
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