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Acrosome reaction-inducing substance triggers two different pathways of sperm intracellular signaling in newt fertilization.
Int J Dev Biol
June 2020
Faculty of Science, Yamagata University, 1-4-12 Kojirakawa, Yamagata, Japan.
The acrosome reaction is induced in the sperm of Cynops pyrrhogaster immediately in response to a ligand protein called acrosome reaction-inducing substance (ARIS) in the egg jelly at fertilization, whereas a spontaneous acrosome reaction occurs time-dependently in correlation with the decline of sperm quality for fertilization. The ARIS-induced acrosome reaction was recently found to be mediated by TRPV4 in association with the NMDA type glutamate receptor, although the intracellular mediators for the acrosome reaction are largely unclear. In the present study, spontaneous acrosome reaction was significantly inhibited by Ni, RN1734, and diltiazem, which blocks Cav3.
View Article and Find Full Text PDFComparison of EDCs removal in full and pilot scale membrane bioreactor plants: Effect of flux rate on EDCs removal in short SRT.
J Environ Manage
December 2017
Middle East Technical University, Department of Environmental Engineering, 06100 Ankara, Turkey.
Currently, it is estimated that over 1 billion people are short of adequate portable water and this is expected to increase to 2.5 billion in the year 2025. Membrane Bioreactors (MBR) are now accepted as important tools to extend the availability of water by facilitating the reuse of wastewaters.
View Article and Find Full Text PDFCalcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.
Toxicol Appl Pharmacol
June 2016
Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, People's Republic of China; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Shijiazhuang 050200, Hebei, People's Republic of China. Electronic address:
Liver fibrosis is the principal cause of morbidity and mortality in patients with iron overload. Calcium channel blockers (CCBs) can antagonize divalent cation entry into renal and myocardial cells and inhibit fibrogenic gene expression. We investigated the potential of CCBs to resolve iron overload-associated hepatic fibrosis.
View Article and Find Full Text PDFNoncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling.
J Pharmacol Exp Ther
March 2016
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom (G.E.J.); Mestrado em Bioprospecção Molecular, Universidade Regional do Cariri, Crato, Brazil (R.B.); and Department of Pharmacology, Cambridge, United Kingdom (A.J.T.)
Citral, eucalyptol, and linalool are widely used as flavorings, fragrances, and cosmetics. Here, we examined their effects on electrophysiological and binding properties of human 5-HT3 receptors expressed in Xenopus oocytes and human embryonic kidney 293 cells, respectively. Data were analyzed using nonlinear mixed-effects modeling to account for random variance in the peak current response between oocytes.
View Article and Find Full Text PDFCharacterizing the binding interactions between P-glycoprotein and eight known cardiovascular transport substrates.
Pharmacol Res Perspect
March 2015
Department of Physics, Coe College Cedar Rapids, IOWA.
The multidrug efflux pump P-glycoprotein (Pgp) is upregulated in cardiomyocytes following chronic ischemia from infarction and hypoxia caused by sleep apnea. This report summarizes the molecular dynamic studies performed on eight cardiovascular drugs to determine their corresponding binding sites on mouse Pgp. Selected Pgp transport ligands include: Amiodarone, Bepridil, Diltiazem, Dipyridamole, Nicardipine, Nifedipine, Propranolol, and Quinidine.
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