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Quercetin-Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/mA/CYP8B1 Signaling.
Adv Sci (Weinh)
January 2025
College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Global health is increasingly challenged by the growing prevalence of obesity and its associated complications. Quercetin, one of the most important dietary flavonoids, is being explored as an effective therapy for obesity with its mechanism remains understudied. Here in this study, it is demonstrated that quercetin intervention significantly reverses obesity-related phenotypes through reshaping the overall structure of microbiota, especially boosting colonization of the beneficial gut commensal Akkermansia muciniphila (A.
View Article and Find Full Text PDFA modulatory role of CG methylation on gene expression in soybean implicates its potential utility in breeding.
Plant Biotechnol J
January 2025
Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
Cytosine methylation (mCG) is an important heritable epigenetic modification, yet its functions remain to be fully defined in important crops. This study investigates mCG in soybean following the loss-of-function mutation of two GmMET1 genes. We generated knockout mutants of GmMET1s by CRISPR-Cas9 and conducted comprehensive methylome and transcriptome analyses.
View Article and Find Full Text PDFDesign, Synthesis and Application of Chiral Spirocyclic Bisindoles.
Angew Chem Int Ed Engl
January 2025
Hong Kong University of Science and Technology, Department of Chemistry, Clear Water Bay, Hong Kong, HONG KONG.
While modifications of the privileged catalyst backbones, such as 1,1'-spirobiindane-7,7'-diol (SPINOL), have led to the development of diverse useful chiral catalysts, the incorporation of heteroarenes in such chiral spirocyclic structures has limitedly known. Herein we report the design of a type of chiral spirocyclic bisindole skeletons where the electronically distinct heteroarenes serve as direct anchor for functional sites. Separate approaches for the synthesis of two different families of such skeletons have been developed via chiral phosphoric acid and rhodium catalysis, respectively.
View Article and Find Full Text PDFPlasticity of Root System Architecture and Whole Transcriptome Responses Underlying Nitrogen Deficiency Tolerance Conferred by a Wild Emmer Wheat QTL.
Plant Cell Environ
January 2025
Department of Evolutionary and Environmental Biology, and Institute of Evolution, University of Haifa, Haifa, Israel.
Our aim was to elucidate mechanisms underlying nitrogen (N)-deficiency tolerance in bread wheat (cultivar Ruta), conferred by a wild emmer wheat QTL (WEW; IL99). We hypothesised that the tolerance in IL99 is driven by enhanced N-uptake through modification of root system architecture (RSA) underscored by transcriptome modifications. Severe N-deficiency (0.
View Article and Find Full Text PDFRevisiting the Effect of Trypsin Digestion Buffers on Artificial Deamidation.
J Am Soc Mass Spectrom
January 2025
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.
Deamidation of asparagine and glutamine residues occurs spontaneously, is influenced by pH, temperature, and incubation time, and can be accelerated by adjacent amino acid residues. Incubation conditions used for proteolytic digestion in bottom-up proteomic studies can induce significant deamidation that affects results, either knowingly or unknowingly. This has prompted studies into modifications to common trypsin digestion protocols to minimize chemical deamidation, including shorter incubation times and specific lysis buffers.
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