Gliomatosis cerebri. Results with radiation therapy.

Background: This review was undertaken to determine the outcome for patients diagnosed in the modern era and treated with radiation therapy.

Methods: Using the tumor registries of six institutions in a large metropolitan area, cases of gliomatosis were identified and retrospectively reviewed.

Results: The clinical course for each patient was unique. Deterioration during treatment, brief stabilization, and reversal of the clinical signs and symptoms with stability and high quality of life at 16 months from diagnosis characterized Patients 1, 2, and 3, respectively.

Conclusions: Radiotherapy for gliomatosis appears to stabilize or improve neurologic function in some patients. Its impact on survival will await additional reports and longer follow-up.