The application of reverse phase high-performance liquid chromatography to the separation and analysis of cephradine and cephalexin is demonstrated. The procedure has been applied to chemicals, pharmaceutical formulations and reaction solutions. The preparation of samples is simple and rapid. Chromatographic conditions are described for both pellicular and small particle columns. The feasibility of determing cephradine and cephalexin in physiological fluids has also been demonstrated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7164/antibiotics.30.397 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic oral beta-lactam combinations for treating tuberculosis.
J Appl Microbiol
October 2024
School of Pharmacy, The University of Sydney, 2006 NSW, Australia.
Article Synopsis
- Tuberculosis (TB) is a significant global health issue, and repurposing existing antimicrobial drugs could enhance treatment options, specifically through the use of beta-lactams in conjunction with beta-lactamase inhibitors.* -
- This study tested seven beta-lactams and two inhibitors for their effectiveness against Mycobacterium tuberculosis and identified that clavulanate significantly boosted the beta-lactam activity compared to avibactam, leading to avibactam's exclusion from further tests.* -
- The research found various combinations of beta-lactams that worked synergistically with clavulanate, while most combinations with second-line TB drugs like moxifloxacin showed negative interactions, highlighting the importance of careful drug pairing
Adsorption mechanism of cefradine on three microplastics: A combined molecular dynamics simulation and density functional theory calculation study.
Sci Total Environ
November 2024
College of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China. Electronic address:
Microplastics and antibiotics are receiving increasing attention as two emerging pollutants in the aquatic ecosystem. The absorption of antibiotics by microplastics can potentially intensify their impact on marine organisms and human health. However, the detailed mechanisms underlying this interaction remain to be elucidated.
View Article and Find Full Text PDFIdentification and biological characteristics of TN-47 isolated from .
Int J Syst Evol Microbiol
April 2024
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, 130000, PR China.
With the widespread use of antibiotics, the incidence of antibiotic resistance in microorganisms has increased. is a trunk borer of pine trees. This study aimed to investigate the antimicrobial and biological characteristics of TN-47 (PP411196), isolated from the gastrointestinal tract of in Jilin Province, PR China.
View Article and Find Full Text PDFDo dietary interventions exert clinically important effects on the bioavailability of β-lactam antibiotics? A systematic review with meta-analyses.
J Antimicrob Chemother
April 2024
Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Background: Managing drug-food interactions may help to achieve the optimal action and safety profile of β-lactam antibiotics.
Methods: We conducted a systematic review with meta-analyses in adherence to PRISMA guidelines for 32 β-lactams. We included 166 studies assessing the impact of food, beverages, antacids or mineral supplements on the pharmacokinetic (PK) parameters or PK/pharmacodynamic (PK/PD) indices.
Improving antibiotic removal and anaerobic digestion performance of discarded cefradine pellets through thermo-alkaline pretreatment.
J Hazard Mater
March 2024
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology (Sun Yat-sen University), Guangzhou 510275, China. Electronic address:
Discarded cefradine pellets (DCP) as the hazardous wastes contain lots of bioavailable sucrose. Anaerobic digestion (AD) may be a promising technology for treating DCP, achieving dual goals of waste treatment and resource recovery. However, high concentration of cefradine will inhibit the AD process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!