AI Article Synopsis
- The study measured levels of blood plasma kininogen, kininases, kallikrein, prekallikrein, and prostaglandin F2a in pregnant women during late saline-induced abortion and after fetal delivery.
- Evidence was found for the release of kinins in the uterus during abortion, triggered by locally activated kallikrein from circulating kininogen.
- The strongest kinin release was linked to a decrease in kininase activity at fetal delivery, and pre-abortive kininase levels were directly related to the duration of the abortion.
Article Abstract
Blood plasma kininogen (K), kininases (KS), kallikrein (KK), prekallikrein (PKK), and PGF2a were estimated in the common circulation of pregnant women during late saline-induced abortion and also in retroplacental blood after foetus delivery. The results provide evidence for intra-uterine kinin release from circulating blood K by locally activated KK from the very beginning of abortion. The greatest kinin release coincided with the strongest KS activity decrease at the time of foetus delivery. The pre-abortive KS levels correlated directly with abortus duration. Uterine PG biosynthesis was activated, but appeared to be a secondary process.
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| http://dx.doi.org/10.1016/0162-3109(96)00023-9 | DOI Listing |
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