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Impact of absolute values and changes in meteorological and air quality conditions on community-acquired pneumonia in Germany.
Int J Biometeorol
December 2024
Institute for Lung Research, German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Centre, Philipps-Universität Marburg, Marburg, Germany.
Community-acquired pneumonia (CAP) is a major global health concern as it is a leading cause of morbidity, mortality and economic burden to the health care systems. In Germany, more than 15,000 people die every year from CAP. Climate change is altering weather patterns, and it may influence the probability and severity of CAP.
View Article and Find Full Text PDFAbyss Aerosols: Drop Production from Underwater Bubble Collisions.
Phys Rev Lett
July 2024
Department of Environmental Science and Engineering, Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Fudan University, Shanghai 200433, China.
Over the past century, drops production mechanisms from bubble bursting have been extensively studied. They include the centrifugal fragmentation of liquid ligaments from the bubble cap during film rupture, the flapping of the cap film, and the disintegration of Worthington jets after cavity collapse. We show here that a dominant fraction of previously identified as "surface bubble bursting" submicron drops are, in fact, generated underwater, in the abyss, inside the bubbles themselves before they have reached the surface.
View Article and Find Full Text PDFImmunometabolic reprogramming of macrophages with inhalable CRISPR/Cas9 nanotherapeutics for acute lung injury intervention.
Acta Biomater
June 2024
Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 510180, PR China. Electronic address:
Acute lung injury (ALI) represents a critical respiratory condition typified by rapid-onset lung inflammation, contributing to elevated morbidity and mortality rates. Central to ALI pathogenesis lies macrophage dysfunction, characterized by an overabundance of pro-inflammatory cytokines and a shift in metabolic activity towards glycolysis. This study emphasizes the crucial function of glucose metabolism in immune cell function under inflammatory conditions and identifies hexokinase 2 (HK2) as a key regulator of macrophage metabolism and inflammation.
View Article and Find Full Text PDFIntegrating Recombinase Polymerase Amplification and Photosensitization Colorimetric Detection in One Tube for Fast Screening of in Formula Milk Powder.
Anal Chem
April 2024
Analytical & Testing Center, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610064, China.
() is a widely existing opportunistic pathogen and thus threatens people with low immunity, especially infants. To prevent the outbreak, a rapid and accurate on-site testing method is required. The current standard culture-based method is time-consuming (3-4 days), while the nucleic acid amplification (PCR)-based detection is mostly carried out in central laboratories.
View Article and Find Full Text PDFImpact of aerosol-boundary layer interactions on PM pollution during cold air pool events in a semi-arid urban basin.
Sci Total Environ
April 2024
Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Collaborative Innovation Center for Western Ecological Safety, Lanzhou University, Lanzhou 730000, China. Electronic address:
Global emission reductions still must address winter fine particulate matter (PM) pollution in urban basins with enclosed terrains and frequent cold air pool (CAP) events when the temperatures within the basin are colder than above it. The effects of urban basin aerosol-boundary layer interactions on PM pollution during CAP events remain unclear. Intensive boundary layer observations in January 2021 and numerical models were used to investigate this issue in the semi-arid urban Lanzhou Basin of China.
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