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Physical compatibility of sulbactam/durlobactam with select intravenous drugs during simulated Y-site administration.
Am J Health Syst Pharm
January 2024
Center for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA.
Article Synopsis
- Sulbactam/durlobactam is an antibiotic combination aimed at treating Acinetobacter baumannii, including resistant strains, and this study examined its compatibility with 95 IV drugs during Y-site administration.
- The study involved mixing sulbactam/durlobactam with other IV drugs and evaluating the mixtures for physical characteristics and any signs of incompatibility like precipitation or turbidity changes.
- Results showed sulbactam/durlobactam was compatible with 86 out of 95 drugs, but incompatibility was noted with several specific drugs, providing crucial information for healthcare providers regarding safe IV drug administration.
Ketamine as advanced second-line treatment in benzodiazepine-refractory convulsive status epilepticus in children.
Epilepsia
April 2023
Neonatal and Pediatric Intensive Care Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Status epilepticus (SE) is one of the most common neurological emergencies in children. To date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines. The main objectives of treatment protocols are to expedite therapeutic decisions and to use fast- and short-acting medications without significant adverse effects.
View Article and Find Full Text PDFIn Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH Therapeutics.
Int J Mol Sci
January 2023
Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman bin Faisal University, Khobar 31441, Saudi Arabia.
The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the tetrahydrobiopterin (BH) biosynthetic pathway. Physiologically, BH plays a crucial role as an essential cofactor for the production of catecholamine neurotransmitters, including epinephrine, norepinephrine and dopamine, as well as the gaseous signaling molecule, nitric oxide. Pathological levels of the cofactor have been reported in a number of disease states, such as inflammatory conditions, neuropathic pain and cancer.
View Article and Find Full Text PDFPaxlovid with Caution: Novel Case of Paxlovid-Induced Tacrolimus Toxicity in a Cardiac Transplant Patient.
Eur J Case Rep Intern Med
September 2022
Division of Pulmonology and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA.
Unlabelled: Tacrolimus is commonly used as a prophylactic against acute rejection in transplant patients. Tacrolimus toxicity has numerous presentations that have been well documented in the literature and can be induced by a wide variety of agents. We present a novel case of tacrolimus toxicity in a cardiac transplant patient induced by outpatient treatment for COVID-19 pneumonia with ritonavir-nirmatrelvir, which was successfully treated with phenytoin therapy.
View Article and Find Full Text PDFFosphenytoin dosing regimen including optimal timing for the measurement of serum phenytoin concentration in pediatric patients.
Brain Dev
November 2022
Department of Pharmacy, Tokyo Women's Medical University, Yachiyo Medical Center, Chiba, Japan.
Introduction: We aimed to evaluate the pediatric fosphenytoin dosing regimen, including optimal timing for the measurement of total serum phenytoin concentration (C).
Methods: We retrospectively investigated pediatric patients with status epilepticus or seizure clusters treated with fosphenytoin between April 2013 and March 2018. Two C measurements were analyzed, one 2-4 h after the loading dose and another before the second dose.
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