Background: The Medlar body represents an adaptive tissue form of the fungi known to cause cutaneous chromomycosis. This study was designed to determine the in vitro viability of Medlar bodies that are found in profusion within lesional epidermis.
Methods: Epidermal scrapings of three indigenous cases from Texas of chromomycosis due to Fonsecaea pedrosoi were collected and periodically cultured to determine the duration of fungal viability.
Results: The causative organism could be recovered 11, 15, and 18 months, respectively, after epidermal scrapings were obtained from the three patients.
Conclusions: This simple but important experiment indicates that Medlar bodies are quite hardy. Thus, clinical lesions may appear after long incubation periods subsequent to traumatic implantation of etiologic fungi. The robust adaptability of the tissue form may also account for the difficulty in achieving a "cure" in cases of chromomycosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-4362.1996.tb03269.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcriptional machinery as an architect of genome structure.
Curr Opin Struct Biol
December 2024
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Bethesda, MD 20892, USA. Electronic address:
Chromatin organization, facilitated by compartmentalization and loop extrusion, is crucial for proper gene expression and cell viability. Transcription has long been considered important for shaping genome architecture due to its pervasive activity across the genome and impact on the local chromatin environment. Although earlier studies suggested a minimal contribution of transcription to shaping global genome structure, recent insights from high-resolution chromatin contact mapping, polymer simulations, and acute perturbations have revealed its critical role in dynamic chromatin organization at the level of active genes and enhancer-promoter interactions.
View Article and Find Full Text PDF[Antenatal management in case of preterm premature rupture of membranes before fetal viability: CNGOF Preterm Premature Rupture of Membranes Guidelines].
Gynecol Obstet Fertil Senol
December 2018
Maternité Notre Dame de Bon Secours, groupe hospitalier Paris Saint-Joseph, DHU risques et grossesse, 185, rue Raymond-Losserand, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, université Paris Descartes, 75014 Paris, France. Electronic address:
Objectives: To evaluate the maternal, perinatal and long-term prognosis in the event of previable premature rupture of the membranes (PROM) and to specify the interventions likely to reduce the risks and improve the prognosis.
Methods: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.
Results: Previable PROM is a rare event whose frequency varies from 0.
Improving search efficiency for systematic reviews of diagnostic test accuracy: an exploratory study to assess the viability of limiting to MEDLINE, EMBASE and reference checking.
Syst Rev
June 2015
School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, S1 4DA, England.
Background: Increasing numbers of systematic reviews evaluating the diagnostic test accuracy of technologies are being published. Currently, review teams tend to apply conventional systematic review standards to identify relevant studies for inclusion, for example sensitive searches of multiple bibliographic databases. There has been little evaluation of the efficiency of searching only one or two such databases for this type of review.
View Article and Find Full Text PDFBiological event composition.
BMC Bioinformatics
June 2012
Department of Computer Science and Software Engineering, Concordia University, 1455 de Maisonneuve Blvd, West, Montréal, Canada.
Background: In recent years, biological event extraction has emerged as a key natural language processing task, aiming to address the information overload problem in accessing the molecular biology literature. The BioNLP shared task competitions have contributed to this recent interest considerably. The first competition (BioNLP'09) focused on extracting biological events from Medline abstracts from a narrow domain, while the theme of the latest competition (BioNLP-ST'11) was generalization and a wider range of text types, event types, and subject domains were considered.
View Article and Find Full Text PDFA simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity.
J Immunol Methods
January 2006
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Room D804, Bethesda, MD 20892-5065, USA.
We demonstrate that the FATAL cytolysis assay can be adapted into a rapid and fluorometric antibody-dependent cellular cytotoxicity assay (RFADCC). The RFADCC relies on double-staining target cells with a membrane dye (PKH-26) and a viability dye (CFSE) prior to the addition of antibody and effector cells. We used the RFADCC to assess dose-dependent and envelope-specific anti-human immunodeficiency virus (HIV) ADCC responses mediated by monoclonal antibody-2G12 and human sera.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!