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Design of experiments method into upgrading pyrolytic oil for sustainable aviation fuel additives by hydrotreating and hydrocracking.
Waste Manag
January 2025
School of Chemical Engineering, University of Birmingham, B15 2TT, Birmingham, UK.
Recycling waste to produce liquid fuels for the automotive and aviation industries is a major global concern, especially in light of the ongoing energy crisis. Because waste is used in thermal conversion processes, the resulting liquid products often require additional processing to reduce their density and viscosity, and to remove oxygenated compounds or pollutants that hinder further utilization. Catalytic hydrogenolytic reactions such as hydrodeoxygenation (HDO) and hydrocracking (HC) have been extensively applied to upgrade pyrolysis oils.
View Article and Find Full Text PDFA comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets.
Int J Pharm
January 2025
Universidade de Coimbra, Faculdade de Farmácia, Coimbra 3000-148 Portugal; i3S, IBMC, Rua Alfredo Allen, Porto 4200-135, Portugal. Electronic address:
The pharmaceutical industry is striving to develop innovative and promising tools, increasingly embracing new data-driven approaches, to understand, improve and accelerate the drug product development process. While extended release (ER) oral formulations offer a number of advantages, including maintenance of therapeutic drug levels, a reduction in dosing frequency, and minimization of side effects, achieving consistent drug release profiles remains a significant challenge. As a critical attribute for drug absorption into systemic circulation, in vitro dissolution testing represents a time-consuming and complex method for the evaluation of such formulations.
View Article and Find Full Text PDFDataset of tensile properties for sub-sized specimens of nuclear structural materials.
Sci Data
January 2025
Idaho National Laboratory, Idaho Falls, ID, USA.
Mechanical testing with sub-sized specimens plays an important role in the nuclear industry, facilitating tests in confined experimental spaces with lower irradiation levels and accelerating the qualification of new materials. The reduced size of specimens results in different material behavior at the microscale, mesoscale, and macroscale, in comparison to standard-sized specimens, which is referred to as the "specimen size effect." Although analytical models have been proposed to correlate the properties of sub-sized specimens to standard-sized specimens, these models lack broad applicability across different materials and testing conditions.
View Article and Find Full Text PDFTesting the Taguchi method to design and analyze integrated disease management strategies, for the control of late blight (Phytophthora infestans) on potato.
Pest Manag Sci
January 2025
Institute of Mechanical, Process & Energy Engineering., Heriot-Watt University, Edinburgh, UK.
Background: Identifying robust integrated pest management (IPM) strategies requires the testing of multiple factors at the same time and assessing their combined effects e.g., on disease control.
View Article and Find Full Text PDFTailored recovery of antioxidant fractions enriched in caffeine and phenolic compounds from coffee pulp using ethanol-modified supercritical carbon dioxide.
Food Res Int
January 2025
Department of Agricultural Chemistry and Food Science, Faculty of Science, C/ Francisco Tomás y Valiente, 7, Universidad Autónoma de Madrid, 28049 Madrid, Spain; Department of Production and Characterization of Novel Foods, Institute of Food Science Research, CIAL (UAM-CSIC), 28049 Madrid, Spain. Electronic address:
Coffee pulp (CP) is the by-product of coffee processing that urgently needs to be revalorized using sustainable technologies. This work applied a design of experiment (DoE) for modeling the extraction of bioactive compounds from CP using supercritical carbon dioxide (sc-CO) with ethanol as a co-solvent under variable conditions (temperature, pressure, and ethanol percentage). Considering extraction efficiency (per unit of CP) and extraction selectivity (per unit of extract), results showed that ethanol percentage significantly enhanced the efficiency of total phenolic content, as well as the selectivity of chlorogenic acid and protocatechuic acid (p < 0.
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