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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2351987 | PMC |
| http://dx.doi.org/10.1136/bmj.313.7058.664 | DOI Listing |
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Long-term monitoring of total suspended matter concentration in fishponds in the Guangdong-Hong Kong-Macao Greater Bay Area.
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Department of Geography, The University of Hong Kong, Pokfulam Road, Hong Kong, 999077, China.
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Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT, 84322, USA; Department of Chemistry, University of Louisiana at Lafayette, 300 East St. Mary Blvd, Lafayette, LA, 70504, USA. Electronic address:
A rapid and accurate biosensor for detecting disease biomarkers at point-of-care is essential for early disease diagnosis and preventing pandemics. CRISPR-Cas12a is a promising recognition element for DNA biosensors due to its programmability, specificity, and deoxyribonuclease activity initiated in the presence of a biomarker. The current electrochemical CRISPR-Cas12a-based biosensors utilize the single-stranded DNA (ssDNA) self-assembled on an electrode surface and covalently modified with the redox indicator, usually methylene blue (MB).
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The key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan, 411105, China. Electronic address:
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Division of Medical Oncology, Yonsei Cancer Center, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
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