We report two cases presenting with severe spontaneous systemic anaphylactic reaction who were subsequently found to have hydatid cyst(s) in one or more intra-abdominal organs. This unusual presentation in otherwise asymptomatic patients, without known precipitating factors, i.e., trauma, or accidental (needle aspiration or surgical) rupture of the cyst emphasizes that physicians in endemic regions should keep a high index of suspicion for the hydatid disease as a possible etiology for seemingly idiopathic anaphylactic reaction.
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