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Vitamin C-Based Gingival Depigmentation Versus Surgical Depigmentation: A Randomized Clinical Trial.
ScientificWorldJournal
January 2025
Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
This study aimed at comparing gingival depigmentation by locally injected vitamin C with surgical depigmentation, in terms of effectiveness and patient acceptability. Forty-two patients presenting with ethnicity-related hyperpigmentation were randomly divided into two groups, Group I ( = 21) was treated with locally injected vitamin C and Group II ( = 21) was treated by surgical depigmentation. The outcome was assessed using Gingival Pigmentation Index (GPI) and Skin Hyperpigmentation Index (SHI).
View Article and Find Full Text PDFAged garlic extract enhances the production of β‑defensin 4 via activation of the Wnt/β‑catenin pathway in mouse gingiva.
Exp Ther Med
February 2025
Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata, Hiroshima 739-1195, Japan.
Periodontal disease is recognized as a chronic multifactorial inflammatory condition initiated by dysbiosis within subgingival plaque biofilms. Antimicrobial peptides exhibit a wide spectrum of antimicrobial action, and thus, provide one of the first lines of host defense against oral pathogens. Aged garlic extract (AGE) is effective for preventing the progression of periodontal disease.
View Article and Find Full Text PDFIncidence of Gingival Recessions in Adolescent Orthodontic Patients Treated With Fixed Appliances and Lingual Retainer.
J Clin Periodontol
January 2025
Section of Orthodontics, Department of Dental Clinical Specialties, Complutense University of Madrid, Madrid, Spain.
Aim: To evaluate risk indicators for gingival recessions (GRs) in the lower anterior teeth of orthodontic patients post treatment and during a retention period of at least 5 years, compared to non-treated controls.
Material And Methods: Eighty-nine orthodontically treated patients who were recession-free before treatment were recruited. Demographic, cephalometric and occlusal records were retrieved before (T1) and after treatment (T2), and periodontal outcomes were clinically evaluated at least 5 years post retention (T3).
Therapeutic effect of mesenchymal stem cell-derived exosome therapy for periodontal regeneration: a systematic review and meta-analysis of preclinical trials.
J Orthop Surg Res
January 2025
College of Stomatology, Chongqing Medical University, Chongqing, 401147 , China.
Background: To assess the therapeutic effects of mesenchymal stem cell (MSC)-derived exosome therapy on periodontal regeneration and identify treatment factors associated with enhanced periodontal regeneration in recent preclinical studies.
Methods: Searches were conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases until October 10, 2024. A risk of bias (ROB) assessment was performed using the SYRCLE tool.
Phage therapy as an alternative strategy for oral bacterial infections: a systematic review.
BMC Oral Health
January 2025
Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Background: Oral infectious diseases, such as dental caries, periodontitis and periapical periodontitis, are often complicated by causative bacterial biofilm formation and significantly impact human oral health and quality of life. Bacteriophage (phage) therapy has emerged as a potential alternative with successful applications in antimicrobial trials. While therapeutic use of phages has been considered as effective treatment of some infectious diseases, related research focusing on oral infectious diseases is few and lacks attention.
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