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Cardiovascular safety of osteoanabolic agents.
J Bone Miner Metab
January 2025
Toranomon Hospital Endocrine Center, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.
Purpose: Several osteoanabolic agents have been developed to build new bone more efficiently than anti-resorptive drugs. Among them, romosozumab, an anti-sclerostin antibody, is a potent pharmacological tool to prevent fractures in osteoporosis patients. The efficacy of romosozumab in preventing osteoporotic fractures is robust.
View Article and Find Full Text PDFMultidisciplinary, multicenter consensus for the care of patients affected with Sturge-Weber syndrome.
Orphanet J Rare Dis
January 2025
Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: Sturge-Weber Syndrome (SWS) is a rare, sporadic neurocutaneous disorder affecting the skin, brain, and eyes, due to somatic activating mutations in GNAQ or, less commonly, GNA11 gene. It is characterized by at least two of the following features: a facial capillary malformation, leptomeningeal vascular malformation, and ocular involvement. The spectrum of clinical manifestations includes headache, seizures, stroke-like events, intellectual disability, glaucoma, facial asymmetry, gingival hyperplasia, etc.
View Article and Find Full Text PDFMangrove-based carbon market projects: What stakeholders need to address during pre-feasibility assessment.
J Environ Manage
January 2025
Ecoresolve, San Francisco, CA, USA; Earth Observation Centre, Institute of Climate Change (IPI), Universiti Kebangsaan Malaysia, Bangi, 43600, Malaysia; Department of Civil Engineering, College of Engineering, American University of Sharjah (AUS), P.O. Box 26666, Sharjah, United Arab Emirates; Department of Geography, University of California-Berkeley, Berkeley, CA, 94709, USA. Electronic address:
Mangrove-based carbon market projects (MbCMP) aim to conserve, protect and restore mangrove habitats in order to generate high quality blue carbon credits via a crediting program, as a contribution to climate change mitigation/adaptation, biodiversity conservation, ecosystem services provision and local socio-economic development. The blue carbon credits generated are transferable, verifiable and sold through carbon markets to earn additional income for governments and local communities. The main aim of the paper is to provide important considerations for pre-field planning, that is, how challenges associated with fieldwork, project implementation, and monitoring reporting and verification (MRV) can be addressed with proper pre-field planning.
View Article and Find Full Text PDFExploring Denosumab in the Treatment of Giant Cell Tumors: Clinical Evidence and Controversies.
J Craniofac Surg
November 2024
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL.
Giant cell tumors (GCTs) are benign but locally aggressive bone neoplasms that primarily affect skeletally mature individuals. They are characterized by a tendency for recurrence and being associated with significant morbidity. Traditional treatment has focused on surgical resection; however, the role of medical therapies, such as Denosumab, a bone anti-resorptive drug, which has been Food and Drug Administration (FDA)-approved for unresectable GCTs since 2013, recently has gained prominence.
View Article and Find Full Text PDFVitamin D Controversies in the Laboratory Medicine: A Review of Clinical Guidelines and Recommendations.
EJIFCC
December 2024
Clinical Analysis Department, Hospital Infanta Elena, Huelva, Spain.
A narrative review of the main guidelines and recommendations published from 2011 up to date about the status of vitamin D deficiency has been carried out. The objective of this review is to discuss the origin of the controversy about the status of this entity, as well as the evolution of the methodological aspects and clinical situations that require vitamin D screening. The results obtained indicate that the criteria defining vitamin D status, according to two studies published in 2011, the Institute of Medicine (IOM) recommendations and the Endocrine Society (ES) guidelines, regardless the affected population.
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