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Genome Analysis of Japanese Yersinia pseudotuberculosis Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global Y. pseudotuberculosis Population.
Microbiol Immunol
January 2025
Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yersinia pseudotuberculosis (Ypt) is a gram-negative bacterium that infects both humans and animals primarily through fecal‒oral transmission. While Ypt causes acute gastroenteritis in humans, an association with Kawasaki disease (KD), a disease that primarily affects infants and young children and causes multisystemic vasculitis, has also been suspected. Although KD represents a significant health concern worldwide, the highest annual incidence rate is reported in Japan.
View Article and Find Full Text PDFElucidation of peptide screen for targeted identification of Yersinia pestis by nano-liquid chromatography tandem mass spectrometry.
Sci Rep
January 2025
Microbiology Division, Defence Research and Developmental Establishment, Jhansi Road, Gwalior, 474002, India.
Yersinia pestis, a Gram-negative bacterium is the causative agent of the fatal communicable disease plague. The disease had a profound impact on human history. Plague bacteria are usually transmitted to humans through the bite of an infected rat flea.
View Article and Find Full Text PDFHotspots of genetic change in Yersinia pestis.
Nat Commun
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions ("hot regions", HRs) that, although comprising a minor fraction of the genome, are hotbeds of genetic variation.
View Article and Find Full Text PDFAn epidemiological modeling investigation of the long-term changing dynamics of the plague epidemics in Hong Kong.
Math Biosci Eng
October 2024
Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong SAR, China.
Article Synopsis
- This study uses dynamic modeling to analyze the transmission of pneumonic plague in Hong Kong from 1902 to 1904, focusing on how human, flea, and rodent populations interact.
- By examining historical data and developing epidemic metrics like reproduction numbers, the research reveals key factors driving outbreaks, such as flea lifespan and rodent populations.
- The findings suggest that effective public health strategies should focus on controlling flea and rodent vectors to help prevent future outbreaks and improve overall disease management.
Human genetic variation reveals FCRL3 is a lymphocyte receptor for .
bioRxiv
December 2024
Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.
is the gram-negative bacterium responsible for plague, one of the deadliest and most feared diseases in human history. This bacterium is known to infect phagocytic cells, such as dendritic cells and macrophages, but interactions with non-phagocytic cells of the adaptive immune system are frequently overlooked despite the importance they likely hold for human infection. To discover human genetic determinants of infection, we utilized nearly a thousand genetically diverse lymphoblastoid cell lines in a cellular genome-wide association study method called Hi-HOST (High-throughput Human in-vitrO Susceptibility Testing).
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