The influence of hypothermic storage upon Citellus undulatus erythrocytes extracted during different functional state of the hibernator: hibernation, artificial awakening in winter and summer activity has been investigated. It has been revealed that the cells of the animals, which were in the state of deep hibernation, showed in vitro higher resistance of the systems providing ionic homeostasis (Na+/K+- and Ca(2+)-pompes and passive permeability) not only in comparison with the cells of non-hibernators but also in comparison with the cells of animals of the same species, which were in different functional states. Seasonal alterations of protein composition of ground squirrel erythrocyte membranes have been also investigated and ionic permeabilities of the monolamellar liposomes constructed from hibernator and non-hibernator erythrocyte membrane lipids have been compared. Results obtained have confirmed that the changes in membrane proteins took place during hibernation and these changes, probably, provided cold resistance to a more considerable extent than the changes of characteristics of lipid bilayer.
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