Objective: To review our series of radical vulvectomies and to compare it with results of conservatif treatment.
Material And Methods: We reviewed the 34 cases of vulvar squamous cell carcinoma treated in Hotel-Dieu de France, between January 1978 and December 1988. The treatment was a radical vulvectomy associated with either ipsilateral inguinofemoral lymphadenectomy (67.64%) or bilateral inguinofemoral and pelvic lymphadenectomy (32.26%).
Results: The age and the clinical presentation were consistent with the world literature as was the incidence of lymph node metastasis correlated with disease stage. The rate of local recurrence was consistent with the world literature (8.82% vs 12%) showing lower risk of urinary incontinence. Seroma and wound dehiscence correlated with stage were 20.6%m 26.5% and 11.8% for stages I, II and III respectively. The 5 year survival correlated with stage for these patients were: 87.5%, 63.1% and 42.8% for stages I, II and III respectively whereas the 5 year survival correlated with lymph nodes metastasis was 78% for node (-) and 42% for node (+).
Conclusion: Between 1978 and 1988,our therapy guideline for vulvar carcinoma was radical total vulvectomy. Modifications to this guideline were made specially in using a more conservative approach and radiotherapy when there was a risk of pelvic node involvement.
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Infect Dis Ther
January 2025
ViiV Healthcare, Madrid, Spain.
Introduction: Dolutegravir (DTG) + lamivudine (3TC) demonstrated high rates of virologic suppression (VS) and low rates of virologic failure (VF), discontinuation, and drug resistance in randomized trials. Real-world evidence can support treatment effectiveness, safety, and tolerability in clinical practice and aid in treatment decisions.
Methods: A systematic literature review (SLR) was conducted to identify studies using DTG + 3TC (January 2013-March 2024).
Dysphagia
January 2025
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
This study aimed to develop the 'Fear of Feeding My Child- A Parental Report (FF-PR)', which measures the parental fear of feeding their children, and to determine its reliability and validity. The study consists of the developmental phase and reported the content validity, internal consistency, test-retest reliability, construct, criterion, and discriminant validity. The study included two groups; 'Group I (N = 90)' who had a neurological disorder and their parents, and 'Group II (N = 60)' who were typically developing children without any feeding and swallowing problems and their parents.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Cerrahpasa Faculty of Medicine, Department of Dermatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Atherosclerosis, in which chronic inflammation is also effective in it's pathogenesis, is an important cause of morbidity and mortality in psoriasis patients. Early diagnosis and management of atherosclerosis is important. Measurement of carotid intima media thickness is a method used to determine subclinical atherosclerosis.
View Article and Find Full Text PDFEpilepsia
January 2025
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
We propose and prioritize important outcome domains that should be considered for future research investigating long-term outcomes (LTO) after new onset refractory status epilepticus (NORSE). The study was led by the international NORSE Institute LTO Working Group. First, literature describing the LTO of NORSE survivors was identified using a PubMed search and summarized to identify knowledge gaps.
View Article and Find Full Text PDFMagn Reson Med
January 2025
Université Grenoble Alpes, INSERM, U1216, Grenoble Institute Neurosciences, GIN, Grenoble, France.
Purpose: This study proposes a novel, contrast-free Magnetic Resonance Fingerprinting (MRF) method using balanced Steady-State Free Precession (bSSFP) sequences for the quantification of cerebral blood volume (CBV), vessel radius (R), and relaxometry parameters (T , T , T *) in the brain.
Methods: The technique leverages the sensitivity of bSSFP sequences to intra-voxel frequency distributions in both transient and steady-state regimes. A dictionary-matching process is employed, using simulations of realistic mouse microvascular networks to generate the MRF dictionary.
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