Sterile culture filtrates from non-typable Haemophilus influenzae (NTHi) grown in medium containing no antibiotics or 0.25 MIC of amoxycillin, ciprofloxacin or loracarbef were examined for their effect on the ciliary beat frequency (CBF) and structure of human respiratory epithelium. CBF slowing was significantly (P < 0.05) less with 0.25 MIC of all three antibiotics. The epithelium was significantly (P < 0.05) less disrupted with ciprofloxacin. The morphology of NTHi infecting human adenoid organ cultures after 24 h with or without 0.25 MIC of the same antibiotics was measured by scanning electron microscopy. Only ciprofloxacin caused a significant (P < 0.05) change in morphology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jac/36.3.545 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insights into bioactivity guided chemical profiling of Mill. fruits wild-growing in Montenegro.
Heliyon
January 2025
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"- National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11108, Belgrade, Serbia.
Jujube ( Mill.) is a highly abundant wild-growing plant in Montenegro. It has been utilized since old times for various bioactive properties by the natives, however its detailed chemical characterization, antimicrobial, antioxidant and cytotoxic potential have not been extensively explored.
View Article and Find Full Text PDFComparative phenotypic and proteomic analysis of colistin-exposed .
Germs
September 2024
PhD, School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam, and Research Center for Infectious Diseases, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam.
Introduction: The emergence of colistin resistance threatens the treatment of infections.
Methods: In this study, in vitro development of colistin resistance was investigated using comparative phenotypic and proteomic analysis of ATCC 9027, its 14-day colistin sub-MIC exposed strain (Col-E1), and 10-day antibiotic-free cultured Col-E1 strain (Col-E2). Antibiotic susceptibility, morphology, virulence factors, and proteomic changes were assessed using disc-diffusion, agar-based, spectrophotometry, SEM, and iTRAQ-LC-MS/MS methods.
Enhanced Bioactivity of Streptomycin Bioconjugated Metal Nanoparticles Against Streptomycin Resistant Sp.
Indian J Microbiol
December 2024
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610 054 China.
Unlabelled: The emergence of multidrug resistance in pathogenic organisms has caused growing concern, especially among healthcare providers, necessitating the development of new antimicrobial compounds. Resistance to metal nanoparticles is more challenging for any pathogen and thus paved a new avenue of research to formulate a new line of drugs combined with metal nanoparticles to treat microbial resistance. In this present investigation, green synthesised silver (AgNP), gold (AuNP), and platinum (PtNP) nanoparticles using the rind extract of the fruit of Garcinia mangostana L.
View Article and Find Full Text PDFAntibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction.
Pharmaceutics
November 2024
Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil.
The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in strains expressing NorA and MepA efflux pumps. Efflux pumps are mechanisms that bacteria use to resist antibiotics by expelling them from the cell. Methodology: Several compounds and antibiotics, such as ciprofloxacin and norfloxacin, were used to evaluate the antimicrobial activity and the ability of the ES/β-CD complex to reverse resistance.
View Article and Find Full Text PDFEmergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae from 2014 - 2021 in Central and Eastern China: a molecular, biological, and epidemiological study.
BMC Microbiol
November 2024
Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Article Synopsis
- - The study investigates two types of Klebsiella pneumoniae: carbapenem-resistant hypervirulent (CR-hvKP) and hypervirulent carbapenem-resistant (hv-CRKP), focusing on their antibiotic resistance and virulence profiles.
- - Researchers identified these strains through whole-genome analysis and several virulence tests, finding that 17.4% were CR-hvKP and 82.6% were hv-CRKP, with CR-hvKP displaying lower resistance to certain antibiotics.
- - The analysis revealed that while CR-hvKP and hv-CRKP had similar virulence potential, a predominant subclone ST11-KL64 emerged with high resistance and virulence, suggesting an evolving threat
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!