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Biosynthesis of 10-Hydroxy-2-Decenoic Acid in Escherichia coli.
Metab Eng
January 2025
Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines, Key Laboratory of Quantitative Synthetic Biology, Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, CN; University of Chinese Academy of Sciences,Beijing, CN. Electronic address:
10-hydroxy-2-decenoic acid (10-HDA), a unique unsaturated fatty acid present in royal jelly, has attracted considerable interest due to its potential medical applications. However, its low concentration in royal jelly and complex conformational structure present challenges for large-scale production. In this study, we designed and constructed a de novo biosynthetic pathway for 10-HDA in Escherichia coli.
View Article and Find Full Text PDFGreasing the wheels of inflammasome formation: regulation of NLRP3 function by S-linked fatty acids.
Biochem Soc Trans
January 2025
School of Biosciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom.
NLRP3 is an inflammasome seeding pattern recognition receptor that initiates a pro-inflammatory signalling cascade in response to changes in intracellular homeostasis that are indicative of bacterial infection or tissue damage. Several types of post-translational modification (PTM) have been identified that are added to NLRP3 to regulate its activity. Recent progress has revealed that NLRP3 is subject to a further type of PTM, S-acylation (or palmitoylation), which involves the reversible addition of long-chain fatty acids to target cysteine residues by opposing sets of enzymes.
View Article and Find Full Text PDFCryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3.
Open Biol
January 2025
Institute of Physical Chemistry, Polish Academy of Sciences , Warsaw, Poland.
The vertebrate visual cycle hinges on enzymatically converting all--retinol (at-ROL) into 11--retinal (11c-RAL), the chromophore that binds to opsins in photoreceptors, forming light-responsive pigments. When struck by a photon, these pigments activate the phototransduction pathway and initiate the process of vision. The enzymatic isomerization of at-ROL, crucial for restoring the visual pigments and preparing them to receive new light stimuli, relies on various enzymes found in both the photoreceptors and retinal pigment epithelium cells.
View Article and Find Full Text PDFEffects of sunflower cake in lamb diets on meat quality and its fatty acid profile.
Trop Anim Health Prod
January 2025
Federal University of Mato Grosso, Cuiabá, MT, 78060-900, Brazil.
This study aimed to evaluate the effects of sunflower cake (SFC) levels (0, 7, 14, 21, and 28% dry matter) in the diet for feedlot lambs on meat quality and its fatty acid profile. Forty crossbreed non castrated hair lambs were fed with experimental diets through 70 days when they were slaughtered and a Longissimus lumborum section were evaluated for physicochemical quality and fatty acid profile. There were no effects of SFC levels (P > 0.
View Article and Find Full Text PDFCompetitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1.
J Lipid Res
January 2025
Finsen Laboratory, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Movement of lipoprotein lipase (LPL) from myocytes or adipocytes to the capillary lumen is essential for intravascular lipolysis and plasma triglyceride homeostasis-low LPL activity in the capillary lumen causes hypertriglyceridemia. The trans-endothelial transport of LPL depends on ionic interactions with GPIHBP1's intrinsically disordered N-terminal tail, which harbors two acidic clusters at positions 5-12 and 19-30. This polyanionic tail provides a molecular switch that controls LPL detachment from heparan sulfate proteoglycans (HSPGs) by competitive displacement.
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