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The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats.
Mol Biol Rep
January 2025
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Background: Exposure to ionizing radiation is inevitable due to its extensive use in industrial and medical applications. The search for effective and safe natural therapeutic agents as alternatives to chemical drugs is crucial to mitigate their side effects. This study aimed to evaluate the effects of citicoline as a standalone treatment or in combination with the anti-hepatotoxic drug silymarin in protecting against liver injury caused by γ-radiation in rats.
View Article and Find Full Text PDFH. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition.
Integr Cancer Ther
January 2025
National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
Objectives: Hepatocellular carcinoma (HCC) represents the third-most prevalent cancer in humans worldwide. The current study's objective is to search for the potentiality of H. Wendl () leaf extract in a nanoemulsion (NE) form in enhancing radiotherapy against HCC induced in rats using diethylnitrosamine (DEN).
View Article and Find Full Text PDFCharacterizing Antimicrobial Effects of Radiation and Antibiotic Interactions on and Using MALDI-TOF MS.
Antibiotics (Basel)
January 2025
Department of Food Microbiology, Hygiene, and Safety, Hungarian University of Agriculture and Life Sciences, H-1118 Budapest, Hungary.
Antibiotic-resistant bacteria are becoming a major challenge in human and veterinary medicine, as well as in food processing. In this study, the protein diversity in antibiotic-sensitive and -resistant strains of and was investigated by exposing them to varying doses of gamma irradiation, with and without antibiotic presence. Changes in bacterial protein profiles were characterized using MALDI-TOF MS to reveal dose-dependent adaptations and potentiation effects under combined irradiation and antibiotic treatments.
View Article and Find Full Text PDFIn vitro regeneration and optimization of physical and chemical mutagenesis protocol in tuberose ( (Medik.) Thiede & Govaerts) cv. 'Arka Vaibhav'.
Int J Radiat Biol
January 2025
ICAR-Indian Institute of Horticultural Research, Bengaluru, India.
Purpose: Tuberose ( [Medik.]) is a vegetatively propagated commercial flower crop with limited genetic variability. Crossing barriers prevailing in tuberose necessitates modern breeding techniques like in vitro mutagenesis to generate variability.
View Article and Find Full Text PDFThe Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice.
Vaccines (Basel)
January 2025
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Background/objectives: COVID-19 vaccines effectively prevent severe disease, but unequal distribution, especially in low- and middle-income countries, has led to vaccine-resistant strains. This highlights the urgent need for alternative vaccine platforms that are safe, thermostable, and easy to distribute. This study evaluates the immunogenicity, stability, and scalability of a dissolved microneedle array patch (MAP) delivering the rS1RS09 subunit vaccine, comprising the SARS-CoV-2 S1 monomer and RS09, a TLR-4 agonist peptide.
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