Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Oral colon-retentive inulin gels protect against radiation-induced hematopoietic and gastrointestinal injury by improving gut homeostasis.
Int J Biol Macromol
December 2024
Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Ionizing radiation-induced injury often occurs in nuclear accidents or large-dose radiotherapy, leading to acute radiation syndromes characterized by hematopoietic and gastrointestinal injuries even to death. However, current radioprotective drugs are only used in hospitals with unavoidable side effects. Here, we heated the aqueous solution of inulin, a polysaccharide dietary fiber, forming colon-retentive gel as a radiation protector in radiotherapy.
View Article and Find Full Text PDFHistological and Molecular Biological Changes in Canine Skin Following Acute Radiation Therapy-Induced Skin Injury.
Animals (Basel)
August 2024
College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Radiation therapy is a crucial cancer treatment, but it can damage healthy tissues, leading to side effects like skin injuries and molecular alterations. This study aimed to elucidate histological and molecular changes in canine skin post-radiation therapy (post-RT) over nine weeks, focusing on inflammation, stem cell activity, angiogenesis, keratinocyte regeneration, and apoptosis. Four male beagles received a cumulative radiation dose of 48 Gy, followed by clinical observations, histological examinations, and an RT-qPCR analysis of skin biopsies.
View Article and Find Full Text PDFNicotine interacts with DNA lesions induced by alpha radiation which may contribute to erroneous repair in human lung epithelial cells.
Ecotoxicol Environ Saf
October 2024
Centre for Radiation Protection Research, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden. Electronic address:
Purpose: Epidemiological studies show that radon and cigarette smoke interact in inducing lung cancer, but the contribution of nicotine in response to alpha radiation emitted by radon is not well understood.
Materials And Methods: Bronchial epithelial BEAS-2B cells were either pre-treated with 2 µM nicotine during 16 h, exposed to radiation, or the combination. DNA damage, cellular and chromosomal alterations, oxidative stress as well as inflammatory responses were assessed to investigate the role of nicotine in modulating responses.
BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome.
Mil Med
August 2024
Humanetics Corporation, Minneapolis, MN 55435, USA.
Article Synopsis
- High doses of ionizing radiation can cause severe health issues, known as hematopoietic acute radiation syndrome, and there's currently no FDA-approved protective measure that can be used before radiation exposure.
- A study with eight rhesus macaques tested the effectiveness of synthetic genistein nanoparticles (BIO 300) as a radioprotectant by comparing its effects on survival and health markers with a control group receiving a vehicle.
- Results indicated that all macaques treated with BIO 300 survived for the entire study while only half of the control group did; treated animals showed less tissue damage, better weight maintenance, and fewer symptoms like fever and anemia post-radiation.*
Revitalizing gut health: Liangxue guyuan yishen decoction promotes akkermansia muciniphila -induced intestinal stem cell recovery post-radiation in mice.
Phytomedicine
September 2024
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China; Medical College of Qinghai University, Xining, PR China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, PR China; State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China. Electronic address:
Article Synopsis
- Liangxue Guyuan Yishen Decoction (LGYD), a traditional Chinese medicine, has shown promising results in treating radiation-induced intestinal injury, but its mechanisms need further exploration for better understanding and potential pharmaceutical development.
- The study investigates how LGYD affects gut microbiota and short-chain fatty acids (SCFA) as part of its therapeutic effects on radiation-induced intestinal injury, utilizing various analytical methods to explore these relationships.
- Results indicate that LGYD enhances recovery from intestinal injury, boosts specific beneficial gut bacteria (like Akkermansia muciniphila), and increases SCFA levels, highlighting its potential as a treatment following high-dose radiation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!