Histochemical investigations of the biochemical defence mechanism in experimental trichinellosis: II. prostaglandin synthase activity.

In this paper, we report on the histochemical localization of prostaglandin synthase (E. C. 1.14.99.1) in mouse muscles following infection with Trichinella spiralis and the dynamics of their changes at different stages of disease. Our studies suggest that increased level of prostaglandin synthase activity in infected muscles of mice may be correlated with the degree of muscle injury by larvae and, perhaps, that increased level of enzyme ameliorates the functioning of muscle. The dynamics of prostaglandin synthase changes corresponds to the dynamic of the studied so far biochemical, histological and immunological indices.