Mouse mutants with hearing impairment are useful for elucidating the pathological processes underlying auditory system defects, as well as for understanding the normal process of auditory development and sensory transduction. Deaf mouse mutants are also valuable for identifying the responsible genes by positional cloning, and are used to expedite the search for genes involved in human deafness. The distribution of candidate genes for deafness across the mouse genome is presented, together with a summary of the key features of the mutants involved. Genetic defects affecting hearing can be grouped into broad categories according to their pathological features. These categories include middle ear defects, morphogenetic inner ear defects, central auditory system defects, peripheral neural defects, neuroepithelial defects, cochleo-saccular defects, and late onset hearing loss. The biological features and molecular basis of each type of hearing impairment are described. Finally, the effects of mutations in orthologous genes involved in the auditory system in humans and mice are compared.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1146/annurev.ge.29.120195.003331 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Soft Artificial Synapse Electronics.
Research (Wash D C)
January 2025
Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
Soft electronics, known for their bendable, stretchable, and flexible properties, are revolutionizing fields such as biomedical sensing, consumer electronics, and robotics. A primary challenge in this domain is achieving low power consumption, often hampered by the limitations of the conventional von Neumann architecture. In response, the development of soft artificial synapses (SASs) has gained substantial attention.
View Article and Find Full Text PDF"Groupitizing": A Visuo-Spatial and Arithmetic Phenomenon.
Open Mind (Camb)
January 2025
Department of Neuroscience, Psychology, Pharmacology, and Child Health, University of Florence, Florence, Italy.
When objects are grouped in space, humans can estimate numerosity more precisely than when they are randomly scattered. This phenomenon, called groupitizing, is thought to arise from the interplay of two components: the subitizing system which identifies both the number of subgroups and of items within each group, and the possibility to perform basic arithmetic operations on the subitized groups. Here we directly investigate the relative role of these two components in groupitizing via an interference (dual task) paradigm.
View Article and Find Full Text PDFMachine-Learning Predictions of Cochlear Implant Functional Outcomes: A Systematic Review.
Ear Hear
January 2025
San Francisco Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, California, USA.
Objectives: Cochlear implant (CI) user functional outcomes are challenging to predict because of the variability in individual anatomy, neural health, CI device characteristics, and linguistic and listening experience. Machine learning (ML) techniques are uniquely poised for this predictive challenge because they can analyze nonlinear interactions using large amounts of multidimensional data. The objective of this article is to systematically review the literature regarding ML models that predict functional CI outcomes, defined as sound perception and production.
View Article and Find Full Text PDFSilent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth?
Indian J Nephrol
June 2024
Mansoura Nephrology and Dialysis Unit, Department of Internal Medicine, Mansoura, Egypt.
Background: It has been claimed that tacrolimus may have harmful effects on the auditory system, where it has been linked to ototoxicity and sensorineural hearing loss (SNHL). We evaluated silent SNHL in kidney transplant recipients (KTRs) receiving tacrolimus and the different factors affecting it compared to healthy controls.
Materials And Methods: In this case control study, hearing functions were studied in 42 KTRs receiving tacrolimus as maintenance immunosuppressive therapy for more than 3 months in comparison to 27 age- and gender-matched healthy subjects using tympanometry, pure-tone audiometry (PTA), extended high frequency audiometry (EHFA), and transient evoked oto-acoustic emissions (TEOAEs).
Evaluation of auditory alerting systems for safe electric scooter operations.
Sci Rep
January 2025
Acoustics Research Centre, University of Salford, The Crescent, Manchester, M5 4WT, UK.
It is well understood that a significant shift away from fossil fuel based transportation is necessary to limit the impacts of the climate crisis. Electric micromobility modes, such as electric scooters and electric bikes, have the potential to offer a lower-emission alternative to journeys made with internal combustion engine vehicles, and such modes of transport are becoming increasingly commonplace on our streets. Although offering advantages such as reduced air pollution and greater personal mobility, the widespread approval and uptake of electric micromobility is not without its challenges.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!