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Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study.
Sci Rep
January 2025
Department of Zoonotic Diseases, National Research Centre, Dokki, Giza, 12622, Egypt.
Toxoplasmosis induced by Toxoplasma gondii is a well-known health threat, that prompts fatal encephalitis increased with immunocompromised patients, in addition, it can cause chorioretinitis, microcephaly, stillbirth in the fetus and even led to death. Standard therapy uses sulfadiazine and pyrimethamine drugs revealed beneficial results during the acute stage, however, it has severe side effects. UPLC-ESI-MS/MS used to explore C.
View Article and Find Full Text PDFCat Scratch Disease in Pediatrics: Who Has Systemic Involvement?
Pediatr Infect Dis J
January 2025
From the Pediatric Infectology Service, Children's Hospital Dr. Ricardo Gutiérrez, Hospital associated with the Faculty of Medicine of the University of Buenos Aires.
Article Synopsis
- Bartonella henselae is the bacteria behind cat scratch disease (CSD), which usually causes swollen lymph nodes but can sometimes lead to serious complications; this study aimed to analyze differences in clinical features between systemic and localized cases in children.
- The study reviewed medical records from a pediatric hospital in Buenos Aires, identifying 197 CSD patients, predominantly aged 8 years, with common symptoms being fever and lymphadenopathy; systemic involvement occurred in 34.5% of cases, often presenting as abscesses in organs like the spleen and liver.
- Findings indicated that patients with systemic diseases exhibited higher rates of fever and elevated C-reactive protein levels; nearly all patients received antibiotic
Intraretinal hemorrhages and detailed retinal phenotype of three patients with Alagille syndrome.
Ophthalmic Genet
October 2024
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Purpose: To explore patterns of disease expression in Alagille syndrome (ALGS).
Methods: Patients underwent ophthalmic examination, optical coherence tomography (OCT) imaging, fundus intravenous fluorescein angiography (IVFA), perimetry and full-field electroretinograms (ffERGs). An adult ALGS patient had multimodal imaging and specialized perimetry.
Anti- activity of rose hip oil-solid lipid nanoparticles.
Food Sci Nutr
May 2024
Foodborne and Waterborne Diseases Research Center Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences Tehran Iran.
is a highly prevalent pathogen, reported from almost all geographical regions of the world. Current anti- drugs are not effective enough in immunocompromised patients, encephalitis, chorioretinitis, and congenital toxoplasmosis. Therefore, the prescription of these drugs has been limited.
View Article and Find Full Text PDFThe Great Imitator Masquerading as Autoimmune Hepatitis and Demystifying as Fulminant Syphilitic Retinitis.
Ocul Immunol Inflamm
April 2024
Department of Ophthalmology, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Article Synopsis
- Syphilis can present with various clinical symptoms, making diagnosis challenging; in this case, a 62-year-old man initially appeared to have autoimmune hepatitis but was later diagnosed with neurosyphilis after developing severe vision problems.
- The patient experienced a drop in vision and underwent multiple tests, including a liver biopsy, which suggested autoimmune causes, leading to steroid treatment that may have worsened his condition.
- Eventually, strong positive serological tests for syphilis and lumbar puncture confirmed the diagnosis, and treatment with systemic penicillin significantly improved his vision and resolved the eye inflammation.
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