Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.
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Genomic epidemiology and antibiotic susceptibility profiling of uropathogenic among children in the United States.
mSphere
October 2023
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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- Researchers analyzed whole-genome sequences from 96 UPEC isolates, focusing on those from children with pyelonephritis and multidrug-resistant ST131 strains.
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Inducible Mega-Mediated Macrolide Resistance Confers Heteroresistance in Streptococcus pneumoniae.
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March 2023
Departments of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
In Streptococcus pneumoniae (), the 5.4 to 5.5 kb Macrolide Genetic Assembly (Mega) encodes an efflux pump (Mef[E]) and a ribosomal protection protein (Mel) conferring antibiotic resistance to commonly used macrolides in clinical isolates.
View Article and Find Full Text PDFMultidrug-Resistant High-Risk and Clonal Lineages Occur in Black-Headed Gulls from Two Conservation Islands in Germany.
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October 2022
Pharmaceutical Microbiology, Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany.
Multidrug-resistant (MDR) , including extended-spectrum β-lactamase (ESBL)-producing and , not only emerge in healthcare settings but also in other habitats, such as livestock and wildlife. The spread of these pathogens, which often combine resistance with high-level virulence, is a growing problem, as infections have become increasingly difficult to treat. Here, we investigated the occurrence of ESBL-producing and in fecal samples from two black-headed gull colonies breeding on two nature conservation islands in Western Pomerania, Germany.
View Article and Find Full Text PDFProcessing of the alaW alaX operon encoding the Ala2 tRNAs in Escherichia coli requires both RNase E and RNase P.
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Department of Genetics, University of Georgia, Athens, Georgia, USA.
The alaW alaX operon encodes the Ala2 tRNAs, one of the two alanine tRNA isotypes in Escherichia coli. Our previous RNA-seq study showed that alaW alaX dicistronic RNA levels increased significantly in the absence of both RNase P and poly(A) polymerase I (PAP I), suggesting a role of polyadenylation in its stability. In this report, we show that RNase E initiates the processing of the primary alaW alaX precursor RNA by removing the Rho-independent transcription terminator, which appears to be the rate limiting step in the separation and maturation of the Ala2 pre-tRNAs by RNase P.
View Article and Find Full Text PDFDistribution of papG alleles among uropathogenic Escherichia coli from reproductive age women.
J Biomed Sci
September 2022
Centre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology, Westmead Hospital, Westmead, NSW, 2145, Australia.
Background: Extraintestinal Escherichia coli (E. coli) causing urinary tract infections (UTIs), and often referred to as uropathogenic E. coli (UPEC), are a major contributor to the morbidity of UTIs and associated healthcare costs.
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