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Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice.
Inflamm Res
January 2025
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
Objective: We aimed to understand the potential therapeutic and anti-inflammatory effects of the phosphodiesterase-4 (PDE4) inhibitor roflumilast in models of pulmonary infection caused by betacoronaviruses.
Methods: Mice were infected intranasally with murine hepatitis virus (MHV-3) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Roflumilast was given to MHV-3-infected mice therapeutically at doses of 1 mg/kg or 10 mg/kg, or prophylactically at 10 mg/kg.
Evaluating Efficacy and Safety of Crisaborole in Managing Childhood Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis.
Br J Hosp Med (Lond)
January 2025
Department of Pediatrics, Taizhou Women and Children's Hospital, Taizhou, Zhejiang, China.
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder globally. Crisaborole, a nonsteroidal topical phosphodiesterase 4 inhibitor (PDE4i), has been utilized in treating AD. Crisaborole regulates the production of inflammatory cytokines, which are usually overactive among AD patients.
View Article and Find Full Text PDFExploring the Therapeutic Landscape: A Narrative Review on Topical and Oral Phosphodiesterase-4 Inhibitors in Dermatology.
Pharmaceutics
January 2025
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Phosphodiesterase-4 (PDE4) is involved in the synthesis of inflammatory cytokines that mediate several chronic inflammatory disorders, including psoriasis and atopic dermatitis. In recent years, the therapeutic armamentarium in dermatology has expanded with the introduction of PDE4 inhibitors, both in oral and topical formulations. PDE4 inhibitors have gained increasing interest due to their remarkable safety record and ease of prescription, as evidenced by the recent influx of literature detailing its off-label uses.
View Article and Find Full Text PDFEffects of Caffeine Intake Combined with Self-Selected Music During Warm-Up on Anaerobic Performance: A Randomized, Double-Blind, Crossover Study.
Nutrients
January 2025
School of Sport Science, Beijing Sport University, Beijing 100084, China.
Background: Both listening to music during warm-up and consuming caffeine before exercise have been independently shown to enhance athletic performance. However, the potential synergistic effects of combining these strategies remain largely unexplored. To date, only two studies have reported additional benefits to combining music during warm-up with a caffeine dose of 3 mg/kg on taekwondo-specific performance tasks.
View Article and Find Full Text PDFImpact of Caffeine Intake on Female Basketball Players' Performance.
Nutrients
January 2025
Performance and Sport Rehabilitation Laboratory, University of Castilla La Mancha, 45071 Toledo, Spain.
Background: This study aimed to analyze the effect of caffeine ingestion on basketball performance in semi-professional female players.
Methods: A double-blind, placebo-controlled, randomized experimental design was conducted, in two different periods separated by a week. Twelve female basketball players ingested 3 mg of caffeine/kg of body mass or a placebo.
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