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Muscle biochemistry and residue accretion in male Oreochromis niloticus fries administered therapeutic, subtherapeutic and overdoses of dietary oxytetracycline.
Fish Physiol Biochem
January 2025
Aquatic Animal Health and Environment Division, ICAR-Central Institute of Brackishwater Aquaculture, Raja Annamalai Puram, Chennai, 600028, Tamil Nadu, India.
Oxytetracycline (OTC), an approved antibiotic for aquaculture, is under strict control and regulatory endeavour. This study compared the effects of oral administration of graded doses of OTC comprising the therapeutic (80 mg/kg biomass/day), subtherapeutic (40 mg) and overdoses (240, 400 and 800 mg) in male Nile tilapia Oreochromis niloticus fries (0.64 ± 0.
View Article and Find Full Text PDFCross-sectional evaluation of medical reversals among National Institute of Health guideline practices implemented during the COVID-19 pandemic: how often did experts err in a time of crisis?
BMJ Open
December 2024
Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
Objective: The COVID-19 pandemic required the rapid and often widespread implementation of medical practices without robust data. Many of these practices have since been tested in large, randomised trials and were found to be in error. We sought to identify incorrect recommendations, or reversals, among National Institute of Health COVID-19 guidelines and Food and Drug Administration (FDA) approvals and authorisations.
View Article and Find Full Text PDFClinical genetic services in the Emilia-Romagna region, Italy: current activity and open issues: a mixed-method study.
J Community Genet
January 2025
Medical Genetics Unit, University Hospital of Parma, Parma, Italy.
In 2002, in the Emilia-Romagna region of Italy, a comprehensive strategic plan was developed with the aim of improving the integration and efficiency of the genetic services. Two decades later, this report aims to explore the current functioning of the regional network, with special focus on clinical genetics in the evolving scenarios. To this aim, we analyzed the activity data of the medical genetics services in the region, to identify and possibly improve currently open issues.
View Article and Find Full Text PDF[Structural benefits on prescription? Exploring potentials and challenges of the pSVV concept in the approval process of digital health applications in Germany].
Z Evid Fortbild Qual Gesundhwes
December 2024
Arbeitsgruppe Data-Driven Innovation, Technische Universität Hamburg (TUHH), Hamburg, Deutschland. Electronic address:
Background: With the introduction of the Digital Healthcare Act (DVG) at the end of 2019, digital health applications (DiGA) were included in the statutory health insurance in Germany. DiGA are digital medical products whose primary function is based on digital technologies. In the definition of the approval process, the term "therapeutic benefit", which is crucial to the evaluation of pharmaceuticals, was expanded to include the broader concept of "positive healthcare effect" ("pVE").
View Article and Find Full Text PDF[Packaging waste in the operating room].
Unfallchirurgie (Heidelb)
February 2025
Klinik für Unfall- und Handchirurgie, Schön Klinik Hamburg, Hamburg, Deutschland.
Background: Climate change is a central issue for our future. The increase in the amount of greenhouse gases in the atmosphere promotes the so-called greenhouse effect, resulting in climate change. Worldwide, the amount of plastic waste amounts to approximately 8 billion tons.
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