Dynamic observation of the national team of swimmers for a period of 3 years demonstrated that physical and psychosomal loadings of competitive sport led to the suppression of local immunity, depending on the level of competitive stress. In a certain number of sportsmen the phenomenon of the complete disappearance of some classes of immunoglobulins and normal antibodies from saliva was registered. The daily rhythms of immune reactions had no influence of the regularities of fluctuations in the levels of immunoglobulins and antibodies at different periods of sporting activities when these changes were most pronounced. Still the peaks of immunoglobulin levels were registered in the morning and those of normal antibodies, in the evening after physical strain. During the period of competitions at the time of a sharp drop in the content of immunoglobulins in saliva a rise in the level of anamnestic antibodies was observed. The dynamics of immune reactions in saliva did not essentially depend on the sex of swimmers. The results of these studies are indicative of the necessity of immunoprophylactic and immunocorrective measures in the group of immunological risk.

Download full-text PDF

Source

Publication Analysis

Top Keywords

local immunity
8
normal antibodies
8
immune reactions
8
[the local
4
immunity reactions
4
reactions swimmers
4
swimmers russian
4
russian all-star
4
all-star team]
4
team] dynamic
4

Similar Publications

Introduction: China implemented a dynamic zero-COVID strategy to curb viral transmission in response to the coronavirus disease 2019 (COVID-19) pandemic. This strategy was designed to inhibit mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. This study explores the dynamics of viral evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations.

View Article and Find Full Text PDF

Mares with endometrosis exhibit histological changes not only in the endometrium but also in the myometrium that suggest possible functional impairment. The molecular background of these changes is not well understood. We hypothesize that the transcriptomic profile of the mare myometrium varies depending on the degree of endometrosis in mares.

View Article and Find Full Text PDF

Aim: Regulatory T cells (Tregs) play a crucial role in the development and progression of atherosclerosis. However, the specific association between Treg immune traits and atherosclerosis and related cardiovascular diseases remains unclear, impeding their potential for clinical therapeutic application.

Method: Fifty-eight Treg-related immune traits were obtained from the latest summary level genome-wide association study, which included 3,757 individuals from Sardinia.

View Article and Find Full Text PDF

Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, progression, and outcomes. Hydroxylation of proline (HYP) is a common post-translational modification directly linked to breast cancer survival and progression. Changes in HYP status lead to alterations in epithelial cell signaling, extracellular matrix remodeling, and immune cell recruitment.

View Article and Find Full Text PDF

Tertiary Lymphoid Structures as a Biomarker in Immunotherapy and Beyond: Advancing Towards Clinical Application.

Cancer Lett

January 2025

. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Tertiary lymphoid structures (TLSs) are ectopic immune cell clusters formed in nonlymphoid tissues affected by persistent inflammation, such as in cancer and prolonged infections. They have features of the structure and function of secondary lymphoid organs, featuring central CD20+ B cells, surrounded by CD3+ T cells, CD21+ follicular dendritic cells, and CD68+ macrophages, with a complex vascular system. TLS formation is governed by lymphotoxin-α1β2, TNF, and chemokines like CCL19, CCL21, and CXCL13, differing from secondary lymphoid organ development in developing later in life at sites of chronic inflammation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!