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Impact of Sex Hormones on Glioblastoma: Sex-Related Differences and Neuroradiological Insights.
Life (Basel)
November 2024
Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.
Glioblastoma (GBM) displays significant gender disparities, being 1.6 times more prevalent in men, with a median survival time of 15.0 months for males compared to 25.
View Article and Find Full Text PDFNeurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine.
J Hazard Mater
December 2024
Zebrafish Translational Medical Research Center, Korea University, Ansan, Gyeonggi-do, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:
Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood. Here, we aimed to analyze the neurological effects of citronellol in zebrafish larvae using behavioral and histological analyses and elucidate the mechanisms underlying its neurotoxicity in vivo.
View Article and Find Full Text PDFProgesterone and allopregnanolone facilitate excitatory synaptic transmission in the infralimbic cortex via activation of membrane progesterone receptors.
Neuroscience
December 2024
Department of Psychology, Concordia University, Montreal, Canada. Electronic address:
Estrogens and progesterone can have rapid effects on neuronal function and can modify the use of spatial navigation strategies dependent upon the prefrontal cortex, striatum, and hippocampus. Here, we assessed the effects of 17β-estradiol (E2), progesterone, and its metabolite allopregnanolone, on evoked excitatory postsynaptic potentials in the infralimbic region of the female rat prefrontal cortex. Field excitatory postsynaptic potentials (fEPSPs) evoked by stimulation of layer I were first characterized by recording responses at multiple depths between the cortical surface and the underlying white matter.
View Article and Find Full Text PDFModelling the effect of allopregnanolone on the resolution of spike-wave discharges.
J Comput Neurosci
December 2024
Department of Applied Mathematics, and Centre for Theoretical Neuroscience, University of Waterloo, 200 University Avenue W, Waterloo, N2L 3G1, ON, Canada.
Article Synopsis
- Childhood absence epilepsy (CAE) is a children's epilepsy that often resolves during adolescence, and this study investigates how the hormone allopregnanolone affects brain circuits involved in this disorder.
- The research used a computational model of various brain neurons and found that allopregnanolone can help reduce spike-wave discharges linked to absence seizures, particularly in the thalamus.
- The study suggests that the beneficial effects of allopregnanolone may vary among individuals based on their brain's connectivity and inhibition levels, paving the way for future research on remission in CAE patients.
A Recent Update on the Role of Estrogen and Progesterone in Alzheimer's Disease.
Cell Biochem Funct
December 2024
Department of Biochemistry, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
Alzheimer's disease (AD), one of the most prevalent neurodegenerative disease responsible for 60%-80% dementia cases globally. The disease is more prevalent among elder females. Female reproductive hormones are found to be essential for cellular activities in brain.
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