Endoscopic laser photodestruction is regarded not only as an independent procedure of treatment but primarily as an important and effective component of combined therapy of lung cancer. Direct-contact destruction of carcinoma of the bronchus and distal segment of the trachea has been performed using YAG:Ne lasers in 32 cases. The procedure has proved highly effective, especially, in combination with radiation therapy. Lysis of tumor in areas remote from the exposed one has been observed. It is suggested that endoscopic laser treatment of tumors offers considerable advantage.
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Alzheimers Dement
December 2024
Merry Life Biomedical Company, Ltd., Tainan City, Taiwan, Taiwan.
Background: Alzheimer's disease (AD) is complex in pathogenesis and related to aging biology, especially in late-onset AD. We identified a novel synthetic curcumin analog TML-6 through the platform of 6 biomarkers of anti-aging, anti-inflammation, and anti-Aβ as the potential AD drug candidate. TML-6 exhibits multi-target effects on AD pathogenesis, including the activation of NrF-2, the regulation of autophagic machinery through mTOR, the inhibition of APP synthesis and reduction of Aβ, the upregulation of ApoE, and the inhibition of microglial activation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Background: Environmental factors account for a considerable percentage of dementia cases. Studies in animal models have shown that environmental enrichment (EE; i.e.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Michigan Alzheimer's Disease Research Center, Ann Arbor, MI, USA.
Background: The integration of Large Language Models (LLMs) like ChatGPT-4 in clinical settings offers potential enhancements in medical practice, particularly in neurology and dementia care. There is rising public usage of ChatGPT-4 for preliminary information gathering. This study aims to evaluate the effectiveness of ChatGPT-4 in responding to neurology-focused queries, with an emphasis on Alzheimer's Disease (AD).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.
Background-: An estimated 8.8 million Indians older than 60 years have dementia. The increase in number of people living with dementia is causing difficultly to meet the need for care and support, particularly people with early-stage dementia.
View Article and Find Full Text PDFThe prevalence of Alzheimer's disease and related disorders (ADRD) is rising, and primary care providers (PCPs) will increasingly play a role in its detection. We developed an evidence-based intervention to facilitate cognitive evaluation in primary care. We then implemented it as a set of web-based trainings which were combined with specific tools embedded in the electronic health record (EHR) for PCPs to use in their practices.
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