In the performed experiment the effect of alloxan on insulin secretion by in situ perfused rat pancreas was determined. It was found that alloxan added to the perfusion medium results in a sudden, short-term release of insulin. This effect is independent on the presence of glucose (6.66 mmol/l) in the perfusion medium. Furthermore, it was observed that glucose at 16.66 mmol/l concentration after alloxan perfusion does not stimulate insulin secretion.
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Department of Chemistry, University of Waterloo, Waterloo, ON, Canada. Electronic address:
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J Surg Res
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Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea; Extracorporeal Circulation Research Team, Chonnam National University Hospital, Gwangju, Republic of Korea. Electronic address:
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