The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163402 | PMC |
| http://dx.doi.org/10.1128/AAC.40.7.1717 | DOI Listing |
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