Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1667427 | PMC |
Publication Analysis
Top Keywords
Similar Publications
17α-Ethynylestradiol alters testicular epigenetic profiles and histone-to-protamine exchange in mice.
Reprod Biol Endocrinol
November 2024
Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.
Spermatogenesis starts with the onset of puberty within the seminiferous epithelium of the testes. It is a complex process under intricate control of the endocrine system. Physiological regulations by steroid hormones in general and by estrogens in particular are due to their chemical nature prone to be disrupted by exogenous factors acting as endocrine disruptors (EDs).
View Article and Find Full Text PDFEvaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase.
Clin Pharmacokinet
October 2024
Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA, 94404, USA.
Article Synopsis
- Firsocostat is a liver-targeted drug being tested for treating metabolic dysfunction-related liver issues, and this study examines its potential drug-drug interactions (DDIs).
- In the research, 80 healthy participants tested firsocostat alone or with other medications to see how it interacts with drugs that either affect or are affected by liver enzymes.
- Results showed firsocostat's levels increased significantly with certain inhibitors but had no impact on other medications, suggesting it can be used safely with some drugs without adjustments but not with strong specific inhibitors like rifampin and cyclosporine A.
The use of a pill containing ethinylestradiol-norgestimate improves female sexuality despite the decrease in circulating androgens: a pilot study.
Eur J Contracept Reprod Health Care
August 2024
University of Modena and Reggio Emilia, Modena, Italy.
Purpose: To evaluate the initial impact of a combined oral contraceptive (COC) containing norgestimate (NGM) on female sexuality and on circulating androgen levels in users.
Materials And Methods: Six months modification in the McCoy Female Sexuality Questionnaire (MFSQ) and testosterone (T) and dehydroepiandrosterone sulphate (DHEAS) serum levels in women starting a monophasic pill containing ethinyl-estradiol (EE) 35 µg and NGM 0.250 mg.
Effects of root-derived organic acids on sorption of pharmaceutically active compounds in sandy topsoil.
Chemosphere
May 2024
Geographical Institute, HUN-REN Research Centre for Astronomy and Earth Sciences, Budaörsi út 45, Budapest H-1112, Hungary; HUN-REN CSFK, MTA Centre of Excellence, Budapest, Konkoly Thege Miklós út 15-17, H-1121, Hungary; Department of Environmental and Landscape Geography, Eötvös Loránd University, Pázmány Péter Sétány 1/C, Budapest H-1117, Hungary.
The presence and fate of pharmaceutically active compounds (PhACs) in agricultural fields are rarely investigated. The present study highlights that root-derived low-molecular-weight organic acids (LMWOAs) affect the mobility of PhACs in cultivated humic Arenosol. Sorption experiments are conducted using three PhACs characterised by different physicochemical properties: carbamazepine (CBZ), 17α-ethinylestradiol (EE2), and diclofenac-sodium (DFC).
View Article and Find Full Text PDFTowards a Light-mediated Gene Therapy for the Eye using Caged Ethinylestradiol and the Inducible Cre/lox System.
Angew Chem Int Ed Engl
February 2024
Heidelberg University, 69120, Heidelberg, Germany.
Increasingly, retinal pathologies are being treated with virus-mediated gene therapies. To be able to target viral transgene expression specifically to the pathological regions of the retina with light, we established an in vivo photoactivated gene expression paradigm for retinal tissue. Based on the inducible Cre/lox system, we discovered that ethinylestradiol is a suitable alternative to Tamoxifen as ethinylestradiol is more amenable to modification with photosensitive protecting compounds, i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!