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The Histomorphology to Molecular Transition: Exploring the Genomic Landscape of Poorly Differentiated Epithelial Endometrial Cancers.
Cells
March 2025
SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP) Pan African Research Institute (PACRI), University of Pretoria, Hartfield, Pretoria 0028, South Africa.
The peremptory need to circumvent challenges associated with poorly differentiated epithelial endometrial cancers (PDEECs), also known as Type II endometrial cancers (ECs), has prompted therapeutic interrogation of the prototypically intractable and most prevalent gynecological malignancy. PDEECs account for most endometrial cancer-related mortalities due to their aggressive nature, late-stage detection, and poor response to standard therapies. PDEECs are characterized by heterogeneous histopathological features and distinct molecular profiles, and they pose significant clinical challenges due to their propensity for rapid progression.
View Article and Find Full Text PDFEffect of abatacept added to mycophenolate mofetil for refractory calcinosis in juvenile dermatomyositis.
Mod Rheumatol Case Rep
March 2025
Department of Infection and Immunology, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Aichi, Japan.
Calcinosis is an intractable condition in juvenile dermatomyositis. The effect of abatacept on calcinosis remains controversial. We describe a case of an 8-year-old boy in whom the addition of abatacept to mycophenolate mofetil was effective against calcinosis in juvenile dermatomyositis.
View Article and Find Full Text PDFIntroduction of oral methadone to high-risk patients with prolonged QT interval: A retrospective study.
J Opioid Manag
March 2025
Department of Clinical Pharmacy Research and Education, Osaka University Graduate School of Pharmaceutical Sciences, Suita, Osaka, Japan.
Objective: Methadone may cause detrimental side effects such as corrected QT (QTc) prolongation. However, methadone may be desirable in patients with advanced cancer and those with heart disease who have intractable pain. Therefore, we aimed to evaluate the safety and efficacy of initiating methadone for cancer pain in patients at high risk of methadone-induced QTc prolongation.
View Article and Find Full Text PDFShort coupled Ventricular Fibrillation in a patient with TRPM4 mutation.
Indian Pacing Electrophysiol J
March 2025
Holy Family Hospital, Mumbai, India.
Inherited channelopathies are a cause of syncope in a structurally normal heart with subtle signs on baseline ECG, but sometimes these signs may be absent. The precipitant may either be a tachy or a bradyarrhythmia needing prompt diagnosis and treatment institution. One such cause is short coupled Ventricular fibrillation (VF) where the baseline ECG has a normal corrected QT interval (QTc) with multiple Ventricular Premature Complexes (VPCs) noted in the ECG especially around an event of syncope.
View Article and Find Full Text PDFCOVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case.
Cureus
February 2025
Internal Medicine, Hamad Medical Corporation, Doha, QAT.
Hiccups manifest as involuntary and repetitive diaphragm contractions, often involving the intercostal muscles. However, the precise underlying mechanism remains incompletely understood but typically benign. During the COVID-19 pandemic, the predominant clinical presentation featured fever, cough, and dyspnea.
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