AI Article Synopsis
- Visipaque, a new non-ionic contrast medium, showed no significant impact on kidney function (GFR) in healthy volunteers and caused fewer changes in tubular function compared to monomeric contrast mediums.
- In predialytic patients, both Visipaque and Omnipaque resulted in small, temporary changes in GFR, with delayed excretion observed, but no significant differences in tubular enzyme excretion or glomerular function between the two.
- More iodine retention was noted in the kidneys after Visipaque compared to monomeric contrast agents, but this retention did not correlate with kidney function changes, indicating Visipaque was well tolerated even in patients with severe renal failure.
Article Abstract
The renal effects of the new dimeric non-ionic contrast medium Visipaque were investigated in healthy volunteers and in patients with severe renal failure. Visipaque caused no changes in GFR after i.v. injections to healthy volunteers and less changes in tubular function than monomeric CM. Small and transient changes in GFR were observed in predialytic patients both with Visipaque and with the monomeric Omnipaque. A delayed excretion of both CM was observed in these patients and no differences were observed between the two CM as far as tubular enzymes excretion and glomerular functional parameters are concerned. More iodine was retained in the kidney after Visipaque than after monomers, but this was not correlated with changes in tubular parameters and in GFR. Thus, Visipaque was well tolerated in subjects with normal renal function and in patients with severe renal failure.
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