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A CT-based subregional radiomics nomogram for predicting local recurrence-free survival in esophageal squamous cell cancer patients treated by definitive chemoradiotherapy: a multicenter study.
J Transl Med
December 2024
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, Xi'an, China.
Article Synopsis
- A study aimed to create an online model to predict local recurrence-free survival (LRFS) in patients with esophageal squamous cell carcinoma (ESCC) after definitive chemoradiotherapy (dCRT).
- Researchers extracted significant features from contrast-enhanced CT images to develop a subregion-based radiomic signature, which proved to be more effective than a tumor-based radiomic signature in predicting outcomes.
- The new subregion-based radiomics model significantly outperformed traditional clinical models and was turned into an online tool (nomogram) that can help calculate LRFS probabilities for patients.
Magnetic Resonance Imaging Features for Distinguishing High-Grade From Low-Grade Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis.
Cureus
October 2024
Neurosurgery, Fluminense Federal University, Niterói, BRA.
Soft tissue sarcomas are malignant tumors characterized by heterogeneity and are associated with a high mortality rate. Histopathological grading is considered a pivotal factor in prognostication and treatment planning. While core needle biopsy exhibits high accuracy in determining tumor histology, it fails in some cases, potentially misclassifying high-grade tumors as low-grade.
View Article and Find Full Text PDFMachine learning-based radiomics prognostic model for patients with proximal esophageal cancer after definitive chemoradiotherapy.
Insights Imaging
November 2024
Department of Radiation Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
Objectives: To explore the role of radiomics in predicting the prognosis of proximal esophageal cancer and to investigate the biological underpinning of radiomics in identifying different prognoses.
Methods: A total of 170 patients with pathologically and endoscopically confirmed proximal esophageal cancer from two centers were enrolled. Radiomics models were established by five machine learning approaches.
Concomitant melanoma and keratoma affecting the equine digit: clinical, pathological, and long-term follow-up findings.
BMC Vet Res
October 2024
Department of Anatomy, Comparative Pathology and Toxicology, University of Córdoba, Córdoba, Spain.
Background: This case report details a long-term follow-up of a hoof melanoma with dermo-epidermal activity (resembling Spreading Superficial Melanoma (SSM)) in a bay horse with a history of a right front hoof keratoma. Melanomas involving the horse's foot are seldom reported and usually diagnosed as anaplastic melanomas based on signalment and post-mortem examination. The clinical-pathological characteristics of the foot melanoma in this bay horse are consistent with SSM-like described in humans, which is considered an intermediate malignant tumour attending their biological behaviour.
View Article and Find Full Text PDFPeritumoral tissue (PTT): increasing need for naming convention.
Br J Cancer
October 2024
Interdisciplinary Research Institute of Grenoble, IRIG-Biosanté, University Grenoble Alpes, CEA, INSERM, UMR 1292, F-38000, Grenoble, France.
Various terms are used to describe non-malignant tissue located in the proximity of a tumor, belonging to the organ from which the tumor originated. Traditionally, these tissues, sometimes called "normal adjacent tissue" have been used as controls in cancer studies, and were considered representative of morphologically healthy, non-cancerous tissue. However, with the advancement of OMIC technologies, such tissues are increasingly recognized to be distinct from both tumor and healthy tissues.
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