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MR lymphangiography with intradermal gadofosveset and human serum albumin in mice and primates.
J Magn Reson Imaging
September 2014
Molecular Imaging Program, NCI, NIH, Bethesda, Maryland, USA.
Purpose: To investigate MR lymphangiography in mice and primates with intradermal Gadofosveset and human serum albumin. Gadofosveset is a US FDA approved small molecule Gadolinium (Gd) chelate (957 Da) which reversibly binds serum albumin and temporally behaves as a macromolecule. As the structure of albumin varies among species, the affinity of Gadofosveset is optimized for human albumin.
View Article and Find Full Text PDFAlbumin-binding MR blood pool agents as MRI contrast agents in an intracranial mouse glioma model.
Magn Reson Med
March 2003
Imaging Division, Mallinckrodt, Inc., St. Louis, Missouri 63110, USA.
Intravenous MRI contrast agents are commonly used to improve the detection of intracranial tumors and other central nervous system (CNS) lesions for diagnosis and treatment planning. Two small-molecule, albumin-binding blood pool contrast agents (MP-2269 and MS-325) of potential clinical significance were evaluated at 1.5 Tesla in a mouse glioma model and compared with an extracellular contrast agent (OptiMARK).
View Article and Find Full Text PDFFirst-pass renal perfusion imaging using MS-325, an albumin-targeted MRI contrast agent.
Invest Radiol
September 1999
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Rationale And Objectives: MR angiography is proving to be a useful clinical study for the diagnosis of vascular disorders of renal arteries. However, its utility in terms of stenosis characterization is still limited. Renal perfusion could provide supplemental information that could allow for a comprehensive evaluation of renal artery stenosis by MR imaging.
View Article and Find Full Text PDFMS-325: a small-molecule vascular imaging agent for magnetic resonance imaging.
Acad Radiol
August 1996
Metasyn, Inc., Cambridge, MA 02142-1118, USA.
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