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Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of .
mBio
September 2024
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Unlabelled: bradyzoites play a critical role in pathology due to their long-term persistence in intermediate hosts and their potential to reactivate, resulting in severe diseases in immunocompromised individuals. Currently, there is no effective treatment for eliminating bradyzoites. Hence, better models of bradyzoite development would facilitate identification of therapeutic targets for bradyzoites.
View Article and Find Full Text PDFToxoplasma gondii bradyzoite-specific BAG1 is nonessential for cyst formation due to compensation by other heat-shock proteins.
Parasit Vectors
July 2024
Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Ministry of Education, Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), 1023-1063 South Shatai Rd, Guangzhou, Guangdong, People's Republic of China, 510515.
Background: Toxoplasma gondii is an opportunistic pathogenic protozoan that infects all warm-blooded animals, including humans, and causes zoonotic toxoplasmosis. The bradyzoite antigen 1 (BAG1), known as heat-shock protein (HSP)30, is a specific antigen expressed during the early stage of T. gondii tachyzoite-bradyzoite conversion.
View Article and Find Full Text PDFConstitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of .
bioRxiv
February 2024
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63130, USA.
bradyzoites play a critical role in pathology due to their long-term persistence in intermediate hosts and their potential to reactivate, resulting in severe diseases in immunocompromised individuals. Currently there is no effective treatment for eliminating bradyzoites. Hence, better models of cyst development would facilitate identification of therapeutic targets for bradyzoites.
View Article and Find Full Text PDFToxoplasma gondii metacaspase 2 is an important factor that influences bradyzoite formation in the Pru strain.
Parasitol Res
July 2020
National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Toxoplasma gondii is an important zoonotic protozoan of the phylum Apicomplexa that can infect nearly all warm-blooded animals. The parasite can exist as the interconvertible tachyzoite or bradyzoite forms, leading to acute or latent infection, respectively. No drug has been reported to penetrate the cyst wall and reduce bradyzoite survival and proliferation till now.
View Article and Find Full Text PDFProteomic and transcriptomic analyses of early and late-chronic Toxoplasma gondii infection shows novel and stage specific transcripts.
BMC Genomics
November 2019
Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, 53706, USA.
Background: The protozoan pathogen Toxoplasma gondii has the unique ability to develop a chronic infection in the brain of its host by transitioning from the fast growing tachyzoite morphology to latent bradyzoite morphology. A hallmark of the bradyzoite is the development of neuronal cysts that are resilient against host immune response and current therapeutics. The bradyzoite parasites within the cyst have a carbohydrate and protein-rich wall and a slow-replication cycle, allowing them to remain hidden from the host.
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