Protein profiling of the myocardium exposed to pressure overload from birth.

Physiol Res

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.

Published: October 1996

Aortic banding induced in 2-day-old (A2) and 6-day-old (A6) male rats increased the left ventricular (LV) weight after 60 days; right ventricular (RV) enlargement occurred in the A2 group only. The concentration of collagenous proteins in the LV was elevated in both experimental groups (more in the A2 rats) at the expenses of sarcoplasmic proteins. Aortic banding also affected the proportion of collagen types (lower collagen I, higher collagen III, V) and myosin light chains (higher LC1/LC2) in the LV. Similar changes of proteins in the RV were less pronounced.

Download full-text PDF

Source

Publication Analysis

Top Keywords

aortic banding
8
protein profiling
4
profiling myocardium
4
myocardium exposed
4
exposed pressure
4
pressure overload
4
overload birth
4
birth aortic
4
banding induced
4
induced 2-day-old
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!