AI Article Synopsis
- The study evaluated the effectiveness of MRI in diagnosing noncancerous liver lesions in LEC rats, using T1- and T2-weighted imaging techniques along with gadolinium contrast.
- Cholangiofibrosis exhibited distinct imaging features, showing low signal intensity on T1 and high intensity on T2, with a significantly prolonged T2 relaxation time, aiding its differentiation from normal liver tissue.
- The MRI characteristics of cholangiofibrosis suggest that it could be used to differentiate this lesion from hepatocellular carcinoma (HCC) effectively.
Article Abstract
We measured MR images of the liver of Long-Evans Cinnamon (LEC) rats with pathologic correlation and assessed the effectiveness of MR imaging (MRI) for diagnosis of noncancerous hepatic lesions. T1- and T2-weighted images of their livers were obtained, and the dynamic and delayed studies after intravenous gadolinium injection were also performed. Cholangiofibrosis showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The T2 relaxation time of cholangiofibrosis was significantly prolonged (p < .01), and the signal intensity ratio of this lesion to muscle on T1-weighted images was significantly lower than that of normal liver parenchyma to muscle (p < .01). The lesion was enhanced immediately after gadolinium injection and the enhancement was prolonged. Among three cases of peliosis hepatis identified, one showed heterogeneous intensities on both T1- and T2-weighted images and the other two showed similar intensity pattern to cholangiofibrosis. The characteristic MR appearance of cholangiofibrosis may be useful to distinguish it from hepatocellular carcinoma (HCC).
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| http://dx.doi.org/10.1016/0730-725x(95)02113-8 | DOI Listing |
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