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Adversity in childhood is robustly associated with persistent pain in adulthood. Neuro-immune interactions are a candidate mechanistic link between childhood adversity and persistent pain, given that both childhood adversity and persistent pain are associated with neural and immune upregulation in adulthood. As such, we aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in humans.
View Article and Find Full Text PDFIdeggyogy Sz
November 2024
HUN-REN-PTE, Klinikai Idegtudomány MR Kutatócsoport, Pécs.
Background And Purpose:
Post-COVID condition (also known as long COVID) is a syndrome characterized by persistent symptoms following a suspected or confirmed SARS-CoV-2 infection, lasting for at least two months and are not attributable to other conditions. The most common symptoms include fatigue, diffuse pain, post-exertional malaise and “brain fog” (impairment of memory and concentration). The pathomechanism of long COVID is the subject of ongoing, intensive research.
View Article and Find Full Text PDFBrain Behav Immun Health
December 2024
University of Stavanger, Dept. of Social Studies, Stavanger, Norway.
Multi-omics research is developing rapidly, offering extensive sample analysis options and advanced statistical solutions to identify and understand complex networks of biomarkers. This review encourages groups in the psychoneuroimmunology field with limited experience in research to embrace these advances. Cross-sectional studies can leverage existing sample collections to provide unique information that complements longitudinal studies, providing insights into which biological systems may warrant further investigation and building fundamental mechanistic knowledge of biological networks.
View Article and Find Full Text PDFNeuroimmunomodulation
December 2024
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.
Background: For over 130 years, scientists have been suggesting that infection and inflammation may play a role in psychosis and other psychiatric disorders. First attempts to treat psychosis by immune-modulating therapies were made early in the last century; however, after the development of antipsychotics in the 1950s, scientific interest shifted away from immunological aspects of psychiatric disorders to the involvement of catecholamines, in particular dopamine, in psychosis.
Summary: Antipsychotic treatment was not as successful as expected, so the 1990s saw renewed interest in inflammation and psychoneuroimmunological research in schizophrenia and beyond.
AIDS Res Treat
September 2024
Department of Medicine Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, USA.
Objectives: We aimed to study self-rated health and psycho-neuroimmunological responses during the initial 6 months after testing positive for human immunodeficiency virus (HIV) and its relationship to health literacy, that is, the ability to take in and understand information about one's illness. Health literacy plays a critical role in patients' ability to adhere to antiretroviral treatment (ART). However, there is a lack of studies on the possible impact of HIV-induced proinflammatory processes on health literacy.
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