AI Article Synopsis
- Animal studies indicate that alpha 2 agonists like clonidine may lessen the body's response to low oxygen levels (hypoxia).
- In a study with eight male subjects, the effect of oral clonidine on their ventilatory responses to sustained hypoxia was assessed, comparing results with a placebo.
- Clonidine significantly decreased both the acute hypoxic response and the hypoxic ventilatory decline compared to the placebo, but did not alter the baseline ventilation or the overall ventilation levels at the end of the hypoxia.
Article Abstract
Animal studies suggest that alpha 2 agonists inhibit the chemoreceptor response to hypoxia. We have examined the effect of oral clonidine on the ventilatory response to sustained, isocapnic hypoxia (SpO2 79.7% (SD 1.1%) for 20 min) in eight male subjects. The hypoxic ventilatory response was measured before and after both clonidine and placebo. Clonidine had no significant effect on baseline ventilation or gas exchange. After clonidine, the acute hypoxic response (AHR) (mean 5.81 (95% confidence limits 1.94, 9.68) litre min-1) was significantly less than control (10.40 (5.97, 14.83) litre min-1) and hypoxic ventilatory decline (HVD) (3.42(2.35, 4.49) litre min-1) was also significantly less than control (6.49(3.92, 9.06) litre min-1) (P < 0.05). After placebo, AHR was similar to control but HVD was significantly larger (6.82(5.28, 8.36) litre min-1) than control (4.79(3.03, 6.55) litre min-1) (P < 0.05). Thus clonidine reduced both AHR and HVD but the absolute level of ventilation at the end of hypoxia was unchanged.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/bja/76.2.214 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Public Health.
Alzheimers Dement
December 2024
National Center for Neurological Disorders, Shanghai, China.
Background: Whether lung function prospectively affects cognitive brain health independent of their overlapping factors remains largely unknown. This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms.
Method: This population-based cohort included 43,1834 non-demented participants with spirometry from the UK Biobank.
Rapid and inexpensive synthesis of liter-scale SiC aerogels.
Nat Commun
August 2024
Key Laboratory of Cryogenics Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China.
Ceramic aerogels are promising materials for thermal insulation and protection under harsh environments. Yet current synthesis methods fail to provide an energy-, time-, and cost-effective route for high-throughput production and large-scale applications, especially for non-oxide ceramic aerogels. Here we reported a way to synthesize SiC aerogels within seconds and over liter scale, with a demonstrated throughput of ~16 L min in a typical lab experiment.
View Article and Find Full Text PDFEnhanced photocatalytic performance of Bi-doped TiO under sunlight and UV light: mechanistic insights and comparative analysis.
Photochem Photobiol Sci
August 2024
Solar Energy Conversion and Nanomaterials Laboratory, Department of Chemistry, Manipal University Jaipur, Jaipur, Rajasthan, 303007, India.
Bismuth-doped metal oxides exhibit favourable photocatalytic features when exposed to both sunlight and UV light. In this approach, Bi/TiO and Bi/TiO photocatalysts were prepared and their structural and optical properties are analysed using various characterization techniques. These developed photocatalysts were further tested for the photocatalytic elimination of Nitrobenzene in UV light and sunlight and compared with the performance of bare TiO.
View Article and Find Full Text PDFRecombinant expression and purification of phenylalanyl-tRNA synthetase from wheat: a long-lasting poly(U)-dependent poly(Phe) synthesis system.
Prep Biochem Biotechnol
September 2024
Department of Materials Sciences and Biotechnology and Department of Applied Chemistry, Graduate School of Science and Engineering, Ehime University, Matsuyama, Ehime, Japan.
Synthetic genes for the two subunits of phenylalanyl-tRNA synthetase (PheRS) from wheat were expressed in . When each gene was induced individually, the α subunit with a cleavable 6 × His tag at the amino terminus was largely soluble, while the β subunit was almost completely insoluble. When the two subunits were co-expressed, a soluble fraction containing the two subunits were obtained.
View Article and Find Full Text PDFA Retrospective Analysis of Sacubitril/Valsartan in Heart Failure and Chronic Kidney Disease.
J Pharm Technol
June 2023
Department of Pharmacy, ProMedica Toledo Hospital and Russell J. Ebeid Children's Hospital, Toledo, OH, USA.
Sacubitril/valsartan has demonstrated benefit for patients with heart failure (HF); however, patients with advanced stages of chronic kidney disease (CKD) as defined by the National Kidney Foundation have historically been underrepresented in landmark HF trials. The goal of this study is to examine the safety and efficacy of sacubitril/valsartan in patients with HF and concomitant CKD stages III to V. This multicenter, retrospective, observational study included adult patients with HF and CKD stages III to V prescribed sacubitril/valsartan during hospital admission or upon discharge from January 2017 through March 2022.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!