Podiatric surgical procedures frequently involve administration of preoperative local anesthesia, and because of the nature of these blocks, it is believed that needle-free injection could greatly enhance this aspect of clinical practice. The object of the study was to determine if needle-free injections with the Biojector were equivalent to needle and syringe injections for ankle, Mayo, neuroma, hallux, and digital anesthetic blocks. The results indicate that needle-free injection with the Biojector is equal to needle and syringe for some anesthesia blocks. More research in this area is needed to determine if technique with the Biojector has an impact on time of anesthesia onset or on level of discomfort and ecchymosis.
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http://dx.doi.org/10.7547/87507315-86-5-195 | DOI Listing |
J Pharm Sci
January 2025
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Protein aggregation, a major concern in biopharmaceutical quality control, can be accelerated by various stresses during clinical handling. This study investigated potential aggregation risk factors during dilution process with syringe handling for intravenous administration. Using γ-globulin and IgG solutions as surrogate models of antibody therapeutics, we examined the effects of high sliding speeds and piston operations of the syringe on protein aggregation during saline dilution.
View Article and Find Full Text PDFClin Oral Investig
January 2025
Department of Restorative Dentistry, Dental Materials, and Endodontics, Bauru School of Dentistry, University of São Paulo, Rua Siqueira Campos, 180, Centro, Vitória da Conquista, Bauru, São Paulo, BA, ZIP: 45.000-455, Brazil.
Objective: This study investigated the associations among endodontic instruments, ultrasonic tips and various final irrigation protocols for removing intracanal and intratubular biofilms in long oval canals.
Methodology: One hundred mandibular premolars inoculated with Enterococcus faecalis were divided into two groups: the control group (CG: n = 10), which received no treatment; and the test groups (n = 30), which included saline (SS), sodium hypochlorite (2.5% NaOCl) and chlorhexidine (2% CHX).
Vet Sci
January 2025
Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-Clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou 510990, China.
The aim of this study was to explore an improved method for extracting rat cerebrospinal fluid (CSF), observing the impact on animal health under conditions of large-scale CSF collection and evaluating the feasibility of repeated collections. A total of 20 rats were anesthetized and fixed in a stereotactic frame. A 26G scalp needle, combined with a 1 mL syringe, was used to puncture the atlanto-occipital membrane and collect approximately 170 μL of CSF.
View Article and Find Full Text PDFLasers Med Sci
January 2025
Department of Endodontics, Faculty of Dentistry, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey.
Objective: This study aims to quantitatively compare the effects of standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), EDDY, photon-initiated photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS) on the apical extrusion of irrigation solutions in teeth with severe canal curvature.
Materials And Methods: Seventy-five teeth with a single root and canal, and curvature angles ranging from 20° to 40°, were selected for this study. Root canal curvatures were measured from buccolingual and mesiodistal radiographs using ImageJ software (version 1.
Retina
February 2025
Disha Eye Hospitals Pvt Ltd, Barrackpore, India.
Purpose: To develop a simple tool to remove retained submacular perfluorocarbon liquid bubbles (R-PFCL) and to inject recombinant tissue plasminogen activator safely in subretinal space in submacular hematomas.
Method: A retrospective, interventional study was performed where a simple homemade micro-viscous fluid control was developed to gain access to subretinal space in a controlled way. The rubber cap of the plunger of a 1-mL syringe was cut; this cut rubber cap of the plunger was fitted inside an empty 1-mL tuberculin syringe, and its end was fitted with the tubings of viscous fluid control of the vitrectomy machine.
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