A long-term potentiation of the rat olfactory cortex slices induced by a high-frequency stimulation is followed by membrane phospholipid changes. Activation of the phosphoinositide metabolism and normalising of phosphatidylethanolamine methylation occurs within 60 min after tetanisation when the potentiation fades. The findings reveal a regulating role of the phospholipid signal system at different stages of the long-term potentiation.
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