In 181 E. coli strains isolated from sick children having chronic pyelonephritis and risk factors of its development, as well as from healthy children, the complex of phenotypic signs, and among them bacterial persistence markers (antilysozyme, anticomplementary and "anti-interferon" activity), adhesive capacity, antibiotic resistance and colicinogenicity, were analyzed. The specific bioprofiles of E. coli, the causative agents of pyelonephritis, were established. The most informative biological characteristics of E. coli were determined and used as the basis for the development of the algorithm for differentiating the causative agents of pyelonephritis from transitory and contaminating flora. The effectiveness of the proposed diagnostic algorithm was confirmed by clinical approbation.
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