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Dehydrothyrsiferol Against Cutaneous Leishmaniasis: Treatment Outcome in a Murine Model.
Mar Drugs
December 2024
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Spain.
One of the most important steps in preclinical drug discovery is to demonstrate the in vivo efficacy of potential leishmanicidal compounds and good characteristics at the level of parasite killing prior to initiating human clinical trials. This paper describes the use of dehydrothyrsiferol (DT), isolated from the red alga , in a pharmaceutical form supported on Sepigel, and the in vivo efficacy against a mouse model of cutaneous leishmaniasis. Studying the ultrastructural effect of DT was also carried out to verify the suspected damage at the cellular level and determine the severity of damages produced in the homeostasis of promastigotes.
View Article and Find Full Text PDFPsychosocial moderators of the association between pain intensity and physical function in people with systemic sclerosis.
J Scleroderma Relat Disord
January 2025
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Background: Pain is a prevalent symptom of systemic sclerosis. While previous studies have demonstrated a correlation between higher pain intensity and lower physical function in individuals with systemic sclerosis, the potentially moderating effect of psychosocial factors on the association has yet to be explored.
Methods: This cross-sectional study used data from a fatigue self-management trial for adults with systemic sclerosis.
Effects of estradiol administration on brain activation and anhedonia in perimenopausal women: A pharmaco-fMRI study.
J Affect Disord
January 2025
Department of Psychiatry, University of North Carolina at Chapel Hill, United States of America. Electronic address:
Background: Half of perimenopausal women experience depressive symptoms, including anhedonia. Anhedonia is associated with dysregulation of the frontostriatal circuit. Both the frontrostriatal circuit and depression may be regulated by the reproductive hormone estradiol (E2).
View Article and Find Full Text PDFNeuromuscular Electrostimulation Increases Microcirculatory Flux in Mixed Etiology Leg Ulcers.
Adv Skin Wound Care
January 2025
Keith Gordon Harding, Mb ChB, CBE, FRCGP, FRCP, FRCS, FLSW, is Professor Emeritus Cardiff University, Cardiff, Wales; Adjunct Professor Monash University Malaysia, Subang Jaya, Selangor, Malaysia; and Co-Founder and Editor in Chief of the International Wound Journal. Melissa Blow, BSc, is Principal Podiatrist, South East Wales Vascular Network, Aneurin Bevan University Health Board, Cardiff, Wales. Faye Ashton, BSc, is Vascular Research Nurse, Leicester Biomedical Research Centre, Glenfield University Hospital, Leicester, United Kingdom. David Bosanquet, MD, is Consultant Vascular Surgeon, South East Wales Vascular Network, Aneurin Bevan University Health Board. Acknowledgments: The authors acknowledge the assistance of Firstkind Ltd, Hawk House, Peregrine Business Park, Gomm Road, High Wycombe, United Kingdom HP13 7DL for sponsoring the study (grant ref: FSK-SPECKLE-001) and provided the NMES devices for the trial. Keith Harding has received payments for consulting work from Firstkind Ltd. The authors have disclosed no other financial relationships related to this article. Submitted November 28, 2023; accepted in revised form April 17, 2024.
Objective: To determine if intermittent neuromuscular electrostimulation (NMES) of the common peroneal nerve increases microvascular flow and pulsatility in and around the wound bed of patients with combined venous and arterial etiology.
Methods: Seven consenting participants presenting with mixed etiology leg ulcers participated in this study. Microvascular flow and pulsatility was measured in the wound bed and in the skin surrounding the wound using laser speckle contrast imaging.
Assessing the efficacy and safety profiles of 0.025% tretinoin in treating axillary hyperpigmentation with acanthosis nigricans: a randomized double-blinded study.
Arch Dermatol Res
January 2025
Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, HRH Princess Maha Chakri Sirindhorn Medical Center, Rangsit- Nakhonnayok Road, Ongkharak, Nakhonnayok, 26120, Thailand.
Acanthosis nigricans (AN) is a dermatological condition, marked by hyperpigmentation and skin thickening, frequently affecting body folds like the axillae. Treatment options for axillary hyperpigmentation remain underexplored. This study evaluated the efficacy of 0.
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