Functional and structural changes in the stomach, vegetative tone, microcirculation, histamine metabolism were studied in 136 male alcoholics. The results allowed the authors to distinguish clinico-pathogenetic variants of chronic alcoholic gastritis which can be used for objective evaluation of the disease severity and serve basis for design of adequate therapy at different stages of the disease progression.
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Genomics
January 2025
Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China; Hangzhou Medical College, Linan District, Hangzhou 311300, China. Electronic address:
Background: Ferroptosis is associated with alcoholic hepatitis (AH); however, the underlying mechanisms remain unclear.
Methods: Changes in iron content and oxidative stress in AH patients and in vivo and in vitro models were analyzed. Iron homeostasis pathways in the livers of patients with AH were investigated using RNA sequencing.
Int J Mol Sci
January 2025
Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Piazza Miraglia 2, 80138 Naples, Italy.
Alpha-Glutathione-S-transferase (alphaGST) is a liver enzyme whose serum levels increase with the worsening of fibrosis in alcoholic and viral chronic hepatitis. Its usefulness in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unexplored. From January 2016 to December 2017, 200 patients with MASLD and 30 controls were enrolled.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Department of Anatomy and Physiology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.
: High fructose intake is associated with non-alcoholic fatty liver disease (NAFLD), a chronic liver disease that is on the rise worldwide. New alternatives for treatment, such as bioactive phytochemicals, are needed. The aim of this study was to investigate the beneficial role of resveratrol in treating non-alcoholic steatohepatitis (NASH).
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Asir Health Cluster, Tarj General Hospital, Bisha 67721, Saudi Arabia.
Metabolic syndrome is a metabolic disorder characterized by hypertension, dyslipidemia, impaired glucose tolerance, and abdominal obesity. Impaired insulin action or insulin resistance initiates metabolic syndrome. The prevalence of insulin resistance is increasing all over the world.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Department of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
: Up until now, behavioral interventions and pharmacological therapies were the main approach available for the management of obesity. Diet and exercise, when used as a singular therapeutic method, are inadequate for a successful outcome. Research shows promising results for the surgical treatment of obesity, especially in the area of bariatric surgery (BaS).
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